Norton Children's Hospital

Summary

Norton Children's Hospital is a medical facility located in Louisville, Kentucky. This center is recognized for care of Brain Tumor, Cancer, Neuroblastoma, Soft Tissue Sarcoma, Acute Lymphoblastic Leukemia and other specialties. Norton Children's Hospital is involved with conducting 281 clinical trials across 486 conditions. There are 16 research doctors associated with this hospital, such as William T. Tse, Edward J. Kim, John Berkenbosch, MD, and Kupper Wintergerst.

Top PIs

Clinical Trials running at Norton Children's Hospital

Brain Tumor

Cancer

Testicular cancer

Bronchopulmonary Dysplasia

Leukemia

Acute Lymphoblastic Leukemia

Burkitt Lymphoma

Biphenotypic Leukemia

Acute Leukemia

Ovarian Carcinoma

Selumetinib vs. Chemotherapy

for Brain Cancer

This trial is comparing a new drug, selumetinib, with standard chemotherapy to treat patients with a specific type of brain tumor. The patients do not have a certain genetic mutation and are not affected by a genetic disorder. Selumetinib works by blocking enzymes needed for tumor growth, while the standard drugs kill or stop tumor cells from dividing.

Recruiting

2 awards

Phase 3

DAY101 vs. Chemotherapy

for Pediatric Brain Cancer

This trial is testing tovorafenib, a medication given alone, in children with a specific type of brain tumor. The drug works by blocking a protein that helps cancer cells grow.

Recruiting

2 awards

Phase 3

Chemotherapy + Radiation Therapy

for Brain Cancer

This phase II trial studies the best approach to combine chemotherapy and radiation therapy (RT) based on the patient's response to induction chemotherapy in patients with non-germinomatous germ cell tumors (NGGCT) that have not spread to other parts of the brain or body (localized). This study has 2 goals: 1) optimizing radiation for patients who respond well to induction chemotherapy to diminish spinal cord relapses, 2) utilizing higher dose chemotherapy followed by conventional RT in patients who did not respond to induction chemotherapy. Chemotherapy drugs, such as carboplatin, etoposide, ifosfamide, and thiotepa, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high energy x-rays or high-energy protons to kill tumor cells and shrink tumors. Studies have shown that patients with newly-diagnosed localized NGGCT, whose disease responds well to chemotherapy before receiving radiation therapy, are more likely to be free of the disease for a longer time than are patients for whom the chemotherapy does not efficiently eliminate or reduce the size of the tumor. The purpose of this study is to see how well the tumors respond to induction chemotherapy to decide what treatment to give next. Some patients will be given RT to the spine and a portion of the brain. Others will be given high dose chemotherapy and a stem cell transplant before RT to the whole brain and spine. Giving treatment based on the response to induction chemotherapy may lower the side effects of radiation in some patients and adjust the therapy to a more efficient one for other patients with localized NGGCT.

Recruiting

1 award

Phase 2