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Iowa Methodist Medical Center

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Des Moines, Iowa 50309

Global Leader in Breast Cancer

Global Leader in Lung Cancer

Conducts research for Cancer

Conducts research for Breast cancer

Conducts research for Ovarian Cancer

347 reported clinical trials

4 medical researchers

Photo of Iowa Methodist Medical Center in Des MoinesPhoto of Iowa Methodist Medical Center in Des MoinesPhoto of Iowa Methodist Medical Center in Des Moines

Summary

Iowa Methodist Medical Center is a medical facility located in Des Moines, Iowa. This center is recognized for care of Breast Cancer, Lung Cancer, Cancer, Breast cancer, Ovarian Cancer and other specialties. Iowa Methodist Medical Center is involved with conducting 347 clinical trials across 477 conditions. There are 4 research doctors associated with this hospital, such as Joshua Lukenbill, Samantha L. Mallory, Robert J. Behrens, and Joshua Luckenbill.

Area of expertise

1

Breast Cancer

Global Leader

Iowa Methodist Medical Center has run 58 trials for Breast Cancer. Some of their research focus areas include:

ER positive
HER2 negative
HER2 positive
2

Lung Cancer

Global Leader

Iowa Methodist Medical Center has run 51 trials for Lung Cancer. Some of their research focus areas include:

Stage IV
Stage III
Stage II

Top PIs

Clinical Trials running at Iowa Methodist Medical Center

Breast Cancer

Lung Cancer

Bladder Cancer

Breast cancer

Cancer

Prostate Cancer

Kidney Cancer

Small Cell Lung Cancer

Pancreatic Cancer

Non-Small Cell Lung Cancer

Image of trial facility.

Durvalumab + Chemotherapy

for Breast Cancer

This phase III trial compares the addition of an immunotherapy drug (durvalumab) to usual chemotherapy versus usual chemotherapy alone in treating patients with MammaPrint High 2 Risk (MP2) stage II-III hormone receptor positive, HER2 negative breast cancer. Immunotherapy with monoclonal antibodies, such as durvalumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs, such as paclitaxel, doxorubicin, and cyclophosphamide work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. There is some evidence from previous clinical trials that people who have a MammaPrint High 2 Risk result may be more likely to respond to chemotherapy and immunotherapy. Adding durvalumab to usual chemotherapy may be able to prevent the cancer from returning for patients with MP2 stage II-III hormone receptor positive, HER2 negative breast cancer.

Recruiting

2 awards

Phase 3

40 criteria

Image of trial facility.

Hormone Therapy with or without Radiation

for Breast Cancer

This Phase III Trial evaluates whether breast conservation surgery and endocrine therapy results in a non-inferior rate of invasive or non-invasive ipsilateral breast tumor recurrence (IBTR) compared to breast conservation with breast radiation and endocrine therapy.

Recruiting

2 awards

Phase 3

13 criteria

Image of trial facility.

Carvedilol

for Preventing Heart Problems in HER2 Positive Breast Cancer

This trial has two cohorts of patients with human epidermal growth factor receptor (HER)-2-positive breast cancer that has spread to other places in the body. All patients must be receiving trastuzumab-based treatment. Both cohorts are being observed for cardiac toxicity. The largest cohort (currently open to accrual) is observational, and contains patients who are taking a beta blocker, ACE inhibitor, or ARB as well as their trastuzumab-based treatment. The goal is to understand how common cardiac problems are in this group of patients at high risk. The smaller cohort (currently closed to accrual) is randomized. Patients in this second cohort are randomized to either carvedilol or no treatment, with the goal of seeing whether carvedilol (used to treat heart failure and high blood pressure) may prevent the heart from side effects of chemotherapy.

Recruiting

2 awards

Phase 3

23 criteria

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