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Ropidoxuridine + Whole Brain Radiation Therapy for Brain Metastasis
Study Summary
This trial studies the side effects and best dose of ropidoxuridine when given with whole brain radiation therapy for brain metastases.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I need more than 8 mg of dexamethasone daily before starting whole brain radiation therapy.I do not have any severe illnesses that could worsen due to the study or prevent me from following the study requirements.My kidneys are functioning well enough (creatinine clearance rate is good).I have severe brain complications due to cancer spread.I have had chemotherapy, targeted therapy, or immunotherapy recently.I am HIV positive with a CD4 count of 250 or higher and on anti-viral therapy.I have had whole brain radiation therapy before.I am mostly self-sufficient and can carry out daily activities.My cancer has spread to my brain, and I am advised to undergo whole brain radiation therapy.My bilirubin levels are within the normal range for my condition.My cancer is a type of germ cell tumor, lymphoma, or leukemia.
- Group 1: Treatment (ropidoxuridine, WBRT)
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What is the participant count in this clinical experiment?
"This research project is not currently recruiting volunteers, as the last data update was on August 24th 2022. If you are searching for alternate studies, there are 2735 clinical trials actively seeking participants with brain cancer and 3 trials involving Ropidoxuridine that need patients to enrol."
Has Ropidoxuridine been accorded authorization by the FDA?
"Taking into account the limited evidence for efficacy and safety of Ropidoxuridine, our team has awarded it a score of 1 on a scale from 1 to 3."
Is this experiment currently accessible to participants?
"At this time, the information on clinicaltrials.gov states that no new patients are being recruited for this trial, which was initially posted in December of 2016 and last updated in August 2022. However, there is still an abundance of other studies actively seeking participants - 2738 to be exact."
What precedent does Ropidoxuridine have in terms of clinical experiments?
"Presently, there are 3 studies concerning Ropidoxuridine underway. None of these analyses have progressed to Phase 3 yet. While the majority of research into this drug is based in Providence, Rhode island, it has been tested at 24 separate sites across the country."
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