Simulated Knee Injury for Quadriceps Adaptation
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to understand how knee injuries affect muscle function, specifically the quadriceps, the large muscle at the front of the thigh. Researchers will simulate a knee injury using methods such as injecting saline (a saltwater solution) or lidocaine (a local anesthetic) to study changes in muscle behavior. This research could lead to better treatments for individuals with real knee injuries. It is suitable for healthy, active young adults without major leg injuries or surgeries. Participants will engage in a single, 2-hour lab session to complete neuromuscular tests. As an Early Phase 1 trial, this research focuses on how the simulated injury impacts muscle function, offering participants the opportunity to contribute to foundational knowledge in injury treatment.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research shows that both treatments in this study have generally been safe in past research.
For the lidocaine injection into the knee, studies have found that a single shot does not harm the cartilage, which is crucial for joint health. Tested on individuals with knee pain, such as those with osteoarthritis, it has not caused serious side effects, indicating it is usually well-tolerated.
Regarding the joint treatment with saline (a saltwater solution), research indicates it is safe for most people. Some studies have examined its effects on the muscles around the knee. While it might cause temporary discomfort, it has not led to major issues.
Both treatments have a history of safety in research, but as with all studies, individual experiences may vary.12345Why are researchers excited about this trial's treatments?
Researchers are excited about these treatments because they explore innovative methods for adapting the quadriceps after knee injuries. Unlike traditional treatments that focus on pain relief and inflammation reduction, this trial uses intra-articular lidocaine and saline-induced joint effusion to simulate knee conditions that can lead to muscle adaptation. Lidocaine acts by temporarily numbing the joint, potentially helping to understand nerve-related changes in muscle function. Meanwhile, the saline injection mimics joint swelling, which might help assess how fluid accumulation affects the quadriceps. These approaches aim to uncover new insights into muscle adaptation and recovery following knee injuries, offering potential pathways for more effective rehabilitation strategies.
What evidence suggests that this trial's treatments could be effective for quadriceps adaptation after knee injury?
In this trial, participants will be divided into groups to study the effects of various knee treatments. Research has shown that injecting lidocaine directly into the knee, as performed in the Deafferentation Group, can reduce pain and may improve muscle function. Studies indicate that lidocaine does not harm knee cartilage, making it a safe option for joint issues. Participants in the Effusion Group will receive a saline injection, known as joint effusion, which can temporarily weaken the quadriceps muscle by increasing joint pressure. This method helps researchers understand how fluid in the joint affects muscle function. Both approaches aim to explore how knee issues impact muscles, potentially guiding future treatments. The Control Group will undergo a sham procedure for comparison.16789
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Intervention
Participants undergo simulated knee injury via intra-articular saline or lidocaine injection, followed by neuromuscular testing
Follow-up
Participants are monitored for motor unit recruitment and quadriceps inhibition post-intervention
What Are the Treatments Tested in This Trial?
Interventions
- Intra-articular Lidocaine
- Joint Effusion via 60 mL Sterile Saline
- Sham injection
How Is the Trial Designed?
3
Treatment groups
Experimental Treatment
Active Control
Placebo Group
60 mL sterile saline injected into knee
Lidocaine (single intra-articular dose)
Sham procedure with fake needle
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Central Florida
Lead Sponsor
Citations
The effects of exercise and intra-articular injections versus ...
The purpose of this scoping review is to examine studies that compare combining exercise and intra-articular knee injections to exercise alone for the ...
2.
researchgate.net
researchgate.net/publication/9023109_Effects_of_Lidocaine_into_Knee_on_QF_Strength_and_EMG_in_Patients_with_ACL_LesionEffects of Lidocaine into Knee on QF Strength and EMG in ...
In our previous study, we found that injection of lidocaine into intact knees reduced the maximal voluntary contraction (MVC) and integrated electromyogram ...
The Influence of a Single Intra-Articular Lidocaine Injection on ...
A single intra-articular knee injection of 2% lidocaine did not influence the chondrocyte viability neither in healthy nor in OA cartilage.
Efficacy and Treatment Response of Intra-articular ...
5. Our results show that intra- articular corticosteroid injections significantly improve knee pain, stiffness, and function in patients with symptomatic knee ...
Adductor canal block versus intra-articular steroid and ...
ACB provides longer lasting analgesia which improves function and QoL in chronic KOA patients up to 3 months without any significant side effects.
The efficacy of intra-articular lidocaine administration in ...
Intra-articular 0.5% lidocaine injection under ultrasound guidance has a potential role in the management of chronic knee pain due to osteoarthritis for a 3- ...
The efficacy of intra-articular lidocaine administration in ...
Conclusions: Intra-articular 0.5% lidocaine injection under ultrasound guidance has a potential role in the management of chronic knee pain due to ...
8.
semanticscholar.org
semanticscholar.org/paper/The-efficacy-of-intra-articular-lidocaine-in-knee-A-Eker-Cok/cb0be6360c179069061df769946b0a8d021436c4The efficacy of intra-articular lidocaine administration in ...
The efficacy of intra-articular lidocaine administration in chronic knee pain due to osteoarthritis: A randomized, double-blind, controlled study. · 17 Citations.
Assessment of the duration and effectiveness of intra ...
Conclusion: In total, 83% of patients experienced some effect of the lidocaine injection. Furthermore, 11.5% of patients experienced complete ...
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