Transcranial Magnetic Stimulation for Chronic Nausea
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores a non-invasive brain therapy called Transcranial Magnetic Stimulation (TMS) to determine its potential in alleviating chronic nausea by influencing stomach function. Researchers aim to identify the optimal brain areas to target and assess how different stimulation patterns affect both stomach activity and nausea. Participants will attend several clinic visits, during which they will receive TMS while sitting comfortably and may be asked to drink water or eat a small meal. Adults who frequently experience nausea and vomiting or have no stomach issues at all may qualify for this trial. As an unphased trial, this study offers a unique opportunity to contribute to groundbreaking research that could lead to new treatments for chronic nausea.
Will I have to stop taking my current medications?
You may need to stop taking certain medications, especially if they significantly lower seizure thresholds or if you are using GLP-1 receptor agonists. The trial does not specify a washout period, but these medications are part of the exclusion criteria.
What prior data suggests that Transcranial Magnetic Stimulation is safe for influencing stomach activity?
Research has shown that Transcranial Magnetic Stimulation (TMS) is generally safe when used correctly. Studies have found it can be safely applied to both healthy individuals and those with brain conditions. Some mild side effects, such as headaches and nausea, have been reported, but these are usually temporary and not serious. TMS has already received approval for other conditions, indicating its reasonable safety. Evidence suggests that most people tolerate TMS well.12345
Why are researchers excited about this trial?
Transcranial Magnetic Stimulation (TMS) is unique because it offers a non-invasive way to treat chronic nausea by using magnetic fields to stimulate nerve cells in the brain. Unlike traditional treatments like medications that often target the stomach or digestive system, TMS directly influences brain activity, which could be beneficial for those who haven't found relief with standard options. Researchers are excited about TMS because it has the potential to provide quicker relief and fewer side effects, offering a promising alternative for individuals suffering from chronic nausea and vomiting.
What evidence suggests that Transcranial Magnetic Stimulation is effective for chronic nausea?
Research shows that Transcranial Magnetic Stimulation (TMS) can affect brain activity, potentially helping with issues like chronic nausea. TMS is a non-invasive technique that uses magnetic fields to stimulate brain cells. Some studies suggest it can influence the connection between the brain and the gut, possibly easing symptoms like nausea. Although researchers are still studying direct evidence for TMS in treating chronic nausea, its ability to change brain circuits related to stomach activity appears promising. Early findings indicate that TMS might reduce nausea by altering how the brain communicates with the stomach. Participants in this trial will receive TMS to further investigate its potential benefits for chronic nausea.678910
Who Is on the Research Team?
David J Levinthal, MD PhD
Principal Investigator
University of Pittsburgh
Are You a Good Fit for This Trial?
This trial is for healthy adults and those with chronic nausea or gastroparesis. Participants will need to visit the clinic multiple times over several months. They should be comfortable receiving non-invasive brain stimulation while seated and consuming water or a test meal during visits.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive Transcranial Magnetic Stimulation (TMS) and undergo gastric filling tasks
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Transcranial Magnetic Stimulation
Trial Overview
The study tests if Transcranial Magnetic Stimulation (TMS) can influence stomach activity by targeting specific brain areas. It explores different TMS patterns' effects on stomach function and how they might alleviate chronic nausea symptoms in sufferers.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Subjects without gastric problems and subjects with Chronic Nausea and Vomiting (CNVS)
Find a Clinic Near You
Who Is Running the Clinical Trial?
David Levinthal
Lead Sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborator
Citations
Future Applications of Central Neuromodulation and ...
This brief review describes recent neurophysiological insights and opportunities to further advance the understanding of pathophysiological neural mechanisms.
NCT07276035 | Brain-Stomach Circuits in Chronic Nausea
Researchers will use a non-invasive method of brain stimulation called Transcranial Magnetic Stimulation (TMS) and will record stomach responses ...
Efficacy of Repetitive Transcranial Magnetic Stimulation ...
The number of binge episodes in the 15 days following the final stimulation session was the primary outcome. Secondary outcomes were the number of vomiting ...
Clinical efficacy of deep transcranial magnetic stimulation ...
Control group: 6 (12%) patients reported drowsiness or difficulty concentrating, 3 (6%) headache, 2 (4%) nausea or dizziness, and 1 (2%) back pain, facial ...
The Journal of ECT
No patients treated with standard rTMS experienced subjective memory impairment or nausea/vomiting, while 82.4% and 32.4% of patients receiving ECT experienced ...
Safety and recommendations for TMS use in healthy subjects ...
Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: Expert Guidelines
Dosage and safety of transcranial magnetic stimulation ...
Additionally, safety profiles for these non-invasive brain stimulation interventions in patients with CMP remain insufficiently reported, with limited data on ...
Comparative incidence rates of mild adverse effects ...
Past research has largely neglected to investigate mild adverse effects (MAEs) to transcranial magnetic stimulation (TMS), including headache and nausea.
Safety Review for Clinical Application of Repetitive ...
rTMS conforming to the current safety guidelines (Tables 3, 4, 5) can be applied safely to both healthy volunteers and patients with acquired brain diseases ...
Evidence Brief: Transcranial Magnetic Stimulation (TMS) for ...
In this section, the authors state "TMS therapy may be effective for treating chronic pain, PTSD, TBI, and opiate addiction" but there is very ...
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