Transcranial Magnetic Stimulation for Chronic Nausea

Overseen By David J Levinthal, MD PhD

Age: 18 - 65

Sex: Any

Trial Phase: Academic

Sponsor: David Levinthal

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

219 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

The goal of this study is to determine whether stimulation of the brain-stomach connection can influence stomach activity in healthy adults and in individuals suffering from chronic nausea. The main questions it aims to answer are:

* What are the best brain sites to influence the stomach?

* What are the effects of different stimulation patterns on stomach activity?

* Does the stimulation affect the sensation of nausea in participants suffering from chronic nausea?

Researchers will use a non-invasive method of brain stimulation called Transcranial Magnetic Stimulation (TMS) and will record stomach responses with skin electrodes on the abdomen.

Participants will:

* Visit the clinic at least once, and for up to 9 times more over the course of several months.

* Receive TMS while sitting in a chair similar to a dentist's chair.

* Drink water or consume a test meal during each study visit.

Who Is on the Research Team?

David J Levinthal, MD PhD

Principal Investigator

University of Pittsburgh

Are You a Good Fit for This Trial?

This trial is for healthy adults and those with chronic nausea or gastroparesis. Participants will need to visit the clinic multiple times over several months. They should be comfortable receiving non-invasive brain stimulation while seated and consuming water or a test meal during visits.

Inclusion Criteria

I am between 21 and 60 years old, with or without a CNVS diagnosis.

Exclusion Criteria

I have a history of serious head injury, metal in my skull, or neurological conditions.

I have a neurodegenerative disease like MS, Parkinson's, or Alzheimer's.

I do not have ongoing psychosis or cognitive issues like hallucinations or confusion.

What Are the Treatments Tested in This Trial?

Interventions

• Transcranial Magnetic Stimulation

Trial Overview The study tests if Transcranial Magnetic Stimulation (TMS) can influence stomach activity by targeting specific brain areas. It explores different TMS patterns' effects on stomach function and how they might alleviate chronic nausea symptoms in sufferers.

How Is the Trial Designed?

Group I: Healthy subjects and CNVS subjects Experimental Treatment 1 Intervention

Subjects without gastric problems and subjects with Chronic Nausea and Vomiting (CNVS)

Who Is Running the Clinical Trial?

David Levinthal

Lead Sponsor

Trials

2

Recruited

260+

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Collaborator

Trials

2,513

Recruited

4,366,000+