Endovascular Techniques for Narrowing of the Vertebral Artery
(VOTER Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial examines the effectiveness of endovascular techniques, a minimally invasive procedure, for individuals with a specific type of stroke. It targets those who have experienced a stroke in the back part of the brain and have stenosis in the vertebral arteries, which supply blood to the brain. The trial is open to participants diagnosed with more than 50% narrowing in one of these arteries and who have had a stroke event in the back part of their brain. As a Phase 2 trial, it measures the treatment's effectiveness in an initial, smaller group, providing an opportunity to contribute to important research.
Do I need to stop my current medications for this trial?
The trial information does not specify if you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that endovascular techniques are safe for treating vertebral artery origin stenosis?
Research has shown that endovascular techniques are generally safe and well-tolerated. These procedures are usually minimally invasive, involving smaller incisions and typically posing less risk to patients. In one study, serious side effects occurred in about 29% of patients, with only 11% related to the device used. Another study found no significant increase in the risk of death or stroke within 30 days after treatment. These findings suggest that endovascular treatments are relatively safe, though they do carry some risks.12345
Why are researchers excited about this trial?
Endovascular techniques are unique because they allow for minimally invasive procedures to treat issues at the origin of the vertebral artery, unlike traditional open surgery methods. Researchers are excited about these techniques because they offer the potential for less recovery time and fewer complications, making them a safer alternative for patients. These approaches utilize catheters and small instruments inserted through blood vessels, providing precision in targeting the problematic artery areas without the need for large incisions.
What evidence suggests that endovascular techniques are effective for stroke with Vertebral Artery Origin Stenosis?
Research has shown that certain medical procedures, known as endovascular techniques, may help treat conditions like Vertebral Artery Origin Stenosis (VAOS), which is linked to strokes. One study found that these techniques can help patients become more independent in their daily activities three months after treatment. In one group, many patients had their blood flow successfully restored. Another study found that about 74% of patients had the affected artery completely closed off. These findings suggest that endovascular methods can effectively improve outcomes for patients with VAOS.16789
Who Is on the Research Team?
Randall Edgell, MD
Principal Investigator
St. Louis University
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive stenting plus medical management for Vertebral Artery Origin Stenosis (VAOS)
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Endovascular Techniques
Find a Clinic Near You
Who Is Running the Clinical Trial?
St. Louis University
Lead Sponsor