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Radiation Therapy

High Dose Re-Irradiation for Cancer (REDIRICT Trial)

N/A

Recruiting

Led By Elizabeth Gore, MD

Research Sponsored by Medical College of Wisconsin

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Patients must be ≥18 years of age receiving definitive or postoperative high dose radiation to volume that includes overlap with previously irradiated OAR(s)

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 24 months

Awards & highlights

REDIRICT Trial Summary

This trial uses a consistent approach to give radiation to tumors and analyze its effects on nearby organs.

Who is the study for?

Adults (18+) with stage I-IV solid tumors previously treated with radiation, now needing high dose re-irradiation. Must have a life expectancy of at least 6 months, an ECOG score of 0-2 indicating they are able to perform daily activities, and acceptable organ function as shown by specific lab values. Pregnant women or those not using contraception are excluded.Check my eligibility

What is being tested?

The trial is testing a standardized approach for re-irradiating patients who have had prior radiation therapy. It focuses on advanced imaging techniques for planning treatment and monitoring the effects on organs at risk (like arteries, nerves, spinal cord) over time.See study design

What are the potential side effects?

Potential side effects include damage to nearby organs or tissues due to high doses of radiation such as inflammation in affected areas, changes in organ function (e.g., gastrointestinal issues), fatigue, skin reactions where the radiation is applied.

REDIRICT Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am 18 or older and getting high dose radiation in an area previously treated.

REDIRICT Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 24 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 24 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 24 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Organ-specific grade 3 toxicity.

Organ-specific grade 4 toxicity.

Organ-specific grade 5 toxicity.

REDIRICT Trial Design

1Treatment groups

Experimental Treatment

Group I: Cancer patients receiving definitive radiation therapy with overlap of a previously treated fieldExperimental Treatment1 Intervention

This is a re-irradiation study in solid tumor patients receiving definitive high dose radiation therapy to treatment volumes that include overlap with previously irradiated organs at risk.

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

Medical College of WisconsinLead Sponsor

610 Previous Clinical Trials

1,162,593 Total Patients Enrolled

Elizabeth Gore, MDPrincipal InvestigatorMedical College of Wisconsin

1 Previous Clinical Trials

120 Total Patients Enrolled

Media Library

Re-irradiation (Radiation Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT05301101 — N/A

Solid Tumors Research Study Groups: Cancer patients receiving definitive radiation therapy with overlap of a previously treated field

Solid Tumors Clinical Trial 2023: Re-irradiation Highlights & Side Effects. Trial Name: NCT05301101 — N/A

Re-irradiation (Radiation Therapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05301101 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the population size of this research project?

"Affirmative. Clinicaltrials.gov has records of this research study being conducted, first listed on June 13th 2022 and last modified on May 19th 2023. Its aims to recruit 120 participants from a single medical centre."

Answered by AI

Is it currently possible for individuals to join this research?

"Affirmative. According to the data provided by clinicaltrials.gov, this ongoing medical trial is currently seeking participants. It was first posted on June 13th 2022 and recently updated on May 19th 2023 and requires enrollment of 120 individuals from one location."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

High Dose Re-Irradiation Utilizing Advanced Deformable Image Registration (DIR) and Individualized Organ At Risk (OAR) Dose Calculations With Organ Specific Toxicity Analysis

Elizabeth Gore 2022. "High Dose Re-Irradiation Utilizing Advanced Deformable Image Registration (DIR) and Individualized Organ At Risk (OAR) Dose Calculations With Organ Specific Toxicity Analysis". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05301101.

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