Diagnostic Tools for Lung Transplant
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores the relationship between certain blood markers, such as dd-cfDNA levels and HLA antibodies, and lung transplant health. Researchers are also evaluating the Molecular Microscope® Diagnostic System to assess its effectiveness in identifying issues in lung transplant biopsies. The trial seeks adults who have received a lung transplant and do not have cancer or multiple organ transplants. Those who have had a lung transplant and wish to contribute to future treatment improvements may find this trial suitable.
As a Phase 2 trial, this research measures the treatment's effectiveness in an initial, smaller group, providing an opportunity to contribute to significant advancements in lung transplant care.
Why are researchers excited about this trial?
Researchers are excited about the Trifecta-Lung cfDNA-MMDx method because it offers a non-invasive way to monitor lung transplant health using cell-free DNA (cfDNA). Unlike traditional biopsies, which require surgical procedures to obtain tissue samples, this technique analyzes DNA fragments from the bloodstream to detect signs of organ rejection or other complications. This approach not only reduces the risk and discomfort associated with invasive procedures but also provides real-time insights into transplant health, potentially leading to earlier interventions and improved patient outcomes.
Who Is on the Research Team?
Philip F Halloran, MD PhD
Principal Investigator
Alberta Transplant Applied Genomics Centre, University of Alberta
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Calibration
Calibration of the Prospera® test for T cell-mediated rejection and lung injury using dd-cfDNA levels against MMDx measurements
Follow-up
Participants are monitored for safety and effectiveness after calibration and testing
What Are the Treatments Tested in This Trial?
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Alberta
Lead Sponsor
One Lambda
Collaborator
Natera, Inc.
Industry Sponsor
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