Menthol Cigarettes for Nicotine Addiction
What You Need to Know Before You Apply
What is the purpose of this trial?
This randomized, double-blind, crossover human laboratory study compares the abuse liability of cigarettes containing menthol and non-menthol cigarette variants, using the participant's usual brand menthol cigarette as a within-subject reference. Participants complete standardized laboratory smoking sessions, behavioral economic tasks, and a naturalistic observational period. The study examines differences in nicotine delivery, smoking behavior, and subjective effects across cigarette types in laboratory and real-world contexts.
Who Is on the Research Team?
Yoo Jin Cho, PhD, MPH
Principal Investigator
Ohio State University Comprehensive Cancer Center
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Phase 1
Participants attend a baseline laboratory visit, smoke their usual brand menthol cigarette, and complete surveys for one week.
Phase 2
Participants attend three laboratory visits to smoke blinded study products and complete various tasks.
Phase 3
Participants use their preferred study product for one week and complete a final laboratory visit.
Follow-up
Participants are monitored for safety and effectiveness after the trial phases.
What Are the Treatments Tested in This Trial?
Interventions
- Impact of Novel vs. Usual Brand Menthol Cigarettes
How Is the Trial Designed?
3
Treatment groups
Experimental Treatment
Participants smoke one Study Cigarette C during one Phase 2 laboratory session (10 puffs over 5 minutes), with puff topography and serial plasma nicotine sampling. Subjective effects, the Cigarette Purchase Task, and the Cross-Price Elasticity Task are completed during the session. Order of exposure to Study Cigarettes A, B, and C is randomized.
Participants smoke one Study Cigarette B during one Phase 2 laboratory session (10 puffs over 5 minutes), with puff topography and serial plasma nicotine sampling. Subjective effects, the Cigarette Purchase Task, and the Cross-Price Elasticity Task are completed during the session. Order of exposure to Study Cigarettes A, B, and C is randomized.
Participants smoke one Study Cigarette A during one Phase 2 laboratory session (10 puffs over 5 minutes), with puff topography and serial plasma nicotine sampling. Subjective effects, the Cigarette Purchase Task, and the Cross-Price Elasticity Task are completed during the session. Order of exposure to Study Cigarettes A, B, and C is randomized.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Ohio State University Comprehensive Cancer Center
Lead Sponsor
National Institute on Drug Abuse (NIDA)
Collaborator
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