PEFA Ablation Technique for Ventricular Tachycardia
(PEFA-VT Trial)
Trial Summary
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of the PEFA VT ablation technique treatment for ventricular tachycardia?
The research highlights that advanced mapping techniques, like those used in the PEFA VT ablation, can help identify critical areas in the heart for successful treatment of ventricular tachycardia. These techniques have been associated with reduced hospitalizations and mortality in patients with recurrent heart rhythm issues.12345
Is the PEFA Ablation Technique for Ventricular Tachycardia safe for humans?
Studies on ventricular tachycardia (VT) ablation, which may include techniques like PEFA, have shown that it is generally safe in clinical practice, with safety evaluated in large groups of patients. However, as with any medical procedure, there are risks of complications, and these can vary based on individual health conditions.678910
How is the PEFA VT ablation technique different from other treatments for ventricular tachycardia?
The PEFA VT ablation technique is unique because it uses Paced Electrogram Feature Analysis to precisely identify and target the areas of the heart responsible for ventricular tachycardia, potentially offering a more accurate and effective treatment compared to traditional methods that rely on broader mapping and ablation strategies.36111213
What is the purpose of this trial?
This trial tests a new procedure that uses a special technique to find and fix areas in the heart causing dangerous rhythms in patients with heart disease and previous heart attacks. The goal is to reduce life-threatening heart rhythm problems better than current treatments.
Research Team
Damian Redfearn, MD
Principal Investigator
Queen's University
Eligibility Criteria
This trial is for adults over 18 with ischemic heart disease and a history of myocardial infarction, who have an ICD implanted and are eligible for catheter ablation. It's not suitable for those unable to consent, with severe heart failure symptoms or mechanical heart valves, blood clot in the heart, contraindication to heparin, life expectancy under one year, recent acute coronary syndrome or prior VT ablation.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo catheter ablation using the PEFA strategy to target VT isthmuses
Follow-up
Participants are monitored for safety and effectiveness after treatment, including assessment of ventricular arrhythmia events and antiarrhythmic medication adjustments
Treatment Details
Interventions
- PEFA VT ablation technique
PEFA VT ablation technique is already approved in Canada for the following indications:
- Ischaemic ventricular tachycardia
Find a Clinic Near You
Who Is Running the Clinical Trial?
Dr. Damian Redfearn
Lead Sponsor
Dr. Damian Redfearn
Lead Sponsor