Airway Opening Pressure for Post-Cardiac Surgery Care

Age: Any Age

Sex: Any

Trial Phase: Academic

Sponsor: Laval University

Disqualifiers: Invasive mechanical ventilation

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores a new method to improve breathing after heart surgery. Researchers aim to determine if directly measuring airway opening pressure (the openness of airways) can enhance post-surgery breathing care. This approach could reduce lung issues, such as difficulty obtaining enough oxygen, for those recovering from heart surgeries like bypass or valve operations. Individuals who have undergone heart surgery and require a breathing machine afterward might be suitable candidates for this trial.

As an unphased trial, this study provides a unique opportunity to contribute to innovative research that could enhance recovery for future heart surgery patients.

Do I need to stop my current medications for the trial?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What prior data suggests that this method is safe for post-cardiac surgery care?

Research is exploring how airway opening pressure after heart surgery might enhance lung function. This involves directly measuring the pressure to determine its effect on post-surgery breathing. Complete safety information is not yet available, as the treatment is still undergoing safety testing. Consequently, the full extent of patient tolerance and potential side effects remains unknown.

The aim is to discover if measuring airway opening pressure can reduce post-surgery breathing issues. As this method is new and still under study, further research is necessary to assess its safety for patients. Participants in these trials are crucial to determining if this approach can safely aid lung recovery after heart surgery. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Researchers are excited about the Airway Opening Pressure technique for post-cardiac surgery care because it offers a new way to manage patients' breathing without relying solely on traditional mechanical ventilation. Most current options involve standard ventilators and oxygen therapy, which can be uncomfortable and carry risks of complications. This technique aims to enhance lung function by optimizing the airway pressure, potentially reducing the need for invasive procedures. By improving air flow in a more natural manner, it could lead to faster recovery times and better overall outcomes for patients after heart surgery.

What evidence suggests that airway opening pressure is effective for post-cardiac surgery care?

Research has shown that measuring the pressure needed to open the airways in patients after heart surgery can reveal issues such as incomplete lung expansion. This can lead to problems with oxygen intake and make breathing more difficult post-surgery. In this trial, participants will have their airway opening pressure measured directly, enabling doctors to tailor breathing support more effectively for each patient. While indirect methods are often used, direct measurement may more accurately identify patients at risk for lung issues after heart surgery. This approach aims to improve recovery by adjusting mechanical ventilation to fit each patient's needs. ^{1 2 6 7 8}

Are You a Good Fit for This Trial?

This trial is for patients who have undergone cardiac surgery and are on mechanical ventilation. It aims to include those interested in improving postoperative care by participating in a study that measures direct airway opening pressure, which could indicate lung issues after surgery.

Inclusion Criteria

I am an adult scheduled for heart surgery and will need help breathing afterwards.

Exclusion Criteria

I am on a breathing machine before my surgery.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Postoperative Observation

Participants are observed for airway opening pressure and other respiratory parameters after cardiac surgery

1 hour

Continuous monitoring in intensive care

Follow-up

Participants are monitored for safety and effectiveness after the initial observation period

7 days

Daily assessments

What Are the Treatments Tested in This Trial?

Interventions

• Airway Opening Pressure

Trial Overview The trial is testing the measurement of airway opening pressure directly in patients after cardiac surgery. The goal is to see if this can help tailor ventilatory strategies better than current indirect methods and improve patient outcomes.

How Is the Trial Designed?

Group I: Post operative cardiac surgery Experimental Treatment 1 Intervention

Who Is Running the Clinical Trial?

Laval University

Lead Sponsor

Trials

439

Recruited

178,000+

Citations

1. clinicaltrials.gov clinicaltrials.gov/study/NCT07189026?term=NA

Study Details | NCT07189026 | Prevalence and ... Significant airway opening pressure suggests incomplete alveolar recruitment at end-expiration, which may contribute to ventilation-perfusion ...

2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC3848671/

Non-invasive ventilation in cardiac surgery: a concise review Non-invasive ventilation to treat postoperative acute respiratory failure has been evaluated more extensively. A failure rate from 10 to 55% was reported.

3. withpower.com withpower.com/trial/phase-surgery-cardiac-5-2025-4206a

Airway Opening Pressure for Post-Cardiac Surgery Care This trial is for patients who have undergone cardiac surgery and are on mechanical ventilation. It aims to include those interested in improving postoperative ...

4. trial.medpath.com trial.medpath.com/clinical-trial/e7c8bff67a9a1219/nct07189026-airway-opening-pressure-cardiac-surgery-patients

Prevalence and Clinical Impact of Airway Opening Pressure in ... Determining the prevalence and clinical relevance of significant airway opening pressure in post-cardiac surgery patients could contribute to more personalized ...

5. journals.lww.com journals.lww.com/md-journal/fulltext/2025/02140/predictive_value_of_respiratory_mechanics_for_the.46.aspx

Predictive value of respiratory mechanics for the risk of... The primary outcome was the incidence of radiographically and clinically defined UPE within the first 24 hours postoperatively, while the ...

6. mdpi.com mdpi.com/2077-0383/12/2/497

Difficult Respiratory Weaning after Cardiac Surgery These data suggest a PAOP greater than 18 mmHg during SBT should be considered a warning sign that the patient is likely to fail weaning.

7. jtd.amegroups.org jtd.amegroups.org/article/view/10021/html

Acute respiratory distress syndrome after cardiac surgery - Rong Mild ARDS: 200 mmHg < PaO2/FiO2 ≤300 mmHg with positive end-expiratory pressure (PEEP) or continuous positive airway pressure ≥5 cmH2O;; Moderate ARDS: 100 mmHg ...

8. ctv.veeva.com ctv.veeva.com/study/prevalence-and-clinical-impact-of-airway-opening-pressure-in-post-cardiac-surgery-patients

Prevalence and Clinical Impact of Airway Opening Pressure in ... Significant airway opening pressure suggests incomplete alveolar recruitment at end-expiration, which may contribute to ventilation-perfusion ...