StrokeCog-BBB to Study Cognitive Outcomes Following Stroke

Overseen By Muhith Musabbir

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Stanford University

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

350 Participants Needed

Trial Summary

What is the purpose of this trial?

The goal of this observational study is to learn about cognitive outcomes in stroke patients. The main question it aims to answer are: 1. Is blood-brain barrier permeability compromised for years after stroke, 2. Is a blood biomarker of imbalanced angiogenesis dysregulated in chronic stroke and 3. Are there biomarkers that separately or together predicts cognitive decline after stroke, and are other MRI, blood, and clinical characteristics that are associated. Participants will undergo cognitive testing and MRIs two years apart. Researchers will compare cognitive outcomes in non-stroke patients who have cardiovascular risk factors to understand the effects of stroke on these outcomes.

Research Team

Marion Buckwalter, MD

Principal Investigator

Stanford University

Eligibility Criteria

Inclusion Criteria

You are 45 years of age or older.

You have a history of coronary artery disease, chest pain or placement of a stent in the peripheral vasculature.

You possess one or more risk factors associated with vascular conditions, such as elevated blood pressure, diabetes, angina, prior myocardial infarction, coronary revascularization surgery or lower limb arteriopathy.

Treatment Details

Participant Groups

Group I: Stroke Experimental Treatment 1 Intervention

Patients who have a history of stroke will be in the first group.

Group II: Control Experimental Treatment 1 Intervention

Patients who do not have a history of stroke, but have a history of cardiovascular risk factors will be in the second group.

Who Is Running the Clinical Trial?

Stanford University

Lead Sponsor

Trials

2,527

Recruited

17,430,000+

University of Manchester

Collaborator

Trials

370

Recruited

621,000+

Columbia University

Collaborator

Trials

1,529

Recruited

2,832,000+