Therapy Options for Post-Traumatic Stress Disorder

Overseen By Sarah Pridgen, MA

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Rush University Medical Center

Must not be taking: Psychotropics

Disqualifiers: Suicidal, Psychosis, Substance use, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

400 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This study will look at:

How practical it is to offer another round of proven therapy. How effective different therapy options are for people who didn't respond to the first treatment.

The goal is to improve personalized care by:

Identifying factors that might predict how someone will respond to a second treatment.

Creating a simple tool to spot people who might not respond to treatment early, so they can start a different option sooner.

The findings will help improve PTSD care by offering better follow-up treatments and matching patients with the approach that works best for them.

Are You a Good Fit for This Trial?

This trial is for English-speaking individuals who have experienced a traumatic event and are diagnosed with PTSD. Participants must be willing to undergo 10 therapy sessions over two weeks, with the possibility of an additional 10 sessions. They should also agree to complete various assessments throughout the study.

Inclusion Criteria

I am fluent in English.

I have experienced a significant traumatic event in my life.

I am willing and able to complete surveys and assessments during the study.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Initial Treatment

Participants receive 10 sessions of Cognitive Processing Therapy

10 weeks

Subsequent Treatment

Participants with high PTSD scores are offered a subsequent course of treatment

Varies

Follow-up

Participants are monitored for safety and effectiveness after treatment

6 months

What Are the Treatments Tested in This Trial?

Interventions

• Cognitive Processing Therapy
• Prolonged Exposure
• Skills Training for Affective and Interpersonal Regulation

Trial Overview The study tests how practical and effective it is to offer another round of proven therapies for PTSD patients who didn't improve after initial treatment. It compares Skills Training, Cognitive Processing Therapy, and Prolonged Exposure to find personalized care approaches.

How Is the Trial Designed?

Group I: Initial Course of Cognitive Processing Therapy Experimental Treatment 1 Intervention

All participants will start in Arm 1 where they receive 10-sessions of Cognitive Processing Therapy.

Group II: Subsequent Treatment Active Control 3 Interventions

At one-week follow up after initial Cognitive Processing Therapy, participants whose scores are 28 or above on the PTSD Checklist for DSM-5 will be offered a subsequent course of treatment.

Who Is Running the Clinical Trial?

Rush University Medical Center

Lead Sponsor

Trials

448

Recruited

247,000+