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Behavioural Intervention

TMS-fMRI for Post-Traumatic Stress Disorder

N/A

Recruiting

Led By Allyson C Rosen, Ph.D.

Research Sponsored by Allyson Rosen

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up during the resting state fmri (rsfmri) session

Awards & highlights

Study Summary

"This trial aims to use a new type of brain stimulation called repetitive pulse transcranial magnetic stimulation (rTMS) to help relieve symptoms of post-traumatic stress disorder (PTSD). The study

Who is the study for?

This trial is for individuals aged 18-55 with PTSD, who can safely undergo MRI and TMS procedures. Participants must be able to understand and sign the consent form, have a confirmed PTSD diagnosis per DSM 5 criteria, and commit to not changing their medication between two fMRI sessions.Check my eligibility

What is being tested?

The study tests whether targeting a new brain area with repetitive pulse transcranial magnetic stimulation (rTMS) while using functional magnetic resonance imaging (fMRI) can help manage PTSD symptoms by altering brain activity. It aims at personalizing rTMS treatment based on brain imaging.See study design

What are the potential side effects?

While the description doesn't list specific side effects, common ones associated with TMS include headache, scalp discomfort during stimulation, lightheadedness, or seizures in very rare cases. fMRI is generally safe but may cause discomfort due to loud noises or claustrophobia.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ during the tms-fmri session

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~during the tms-fmri session

This trial's timeline: 3 weeks for screening, Varies for treatment, and during the tms-fmri session for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Changes in Connectivity after cTBS

FMRI BOLD Response

Resting-State fMRI Connectivity

Trial Design

1Treatment groups

Experimental Treatment

Group I: TMS-fMRIExperimental Treatment1 Intervention

Participants will undergo simultaneous TMS-fMRI as part of this study. There will be two locations stimulated: one control region and one target region. Participants will be randomized with respect to the order of receiving stimulation at the locations, but all participants will receive stimulation at both locations as part of the study. All participants will be considered as one group but order effects will be evaluated as an explanatory variable.

Do I qualify?Apply below to find out

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Who is running the clinical trial?

Allyson RosenLead Sponsor

National Institute of Mental Health (NIMH)NIH

2,786 Previous Clinical Trials

2,689,679 Total Patients Enrolled

Allyson C Rosen, Ph.D.Principal InvestigatorPAVIR/Palo Alto VAHCS/Stanford University

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the current number of participants enrolled in this clinical investigation?

"Affirmative, information from clinicaltrials.gov affirms that patient recruitment is ongoing for this trial. The study was made public on August 2nd, 2023 and last revised on April 1st, 2024. Recruitment aims to enroll a total of 30 participants across one site."

Answered by AI

Is the enrollment phase of this medical study currently accepting participants?

"The details on clinicaltrials.gov show that this current research study is actively seeking participants. It was first listed on 8/2/2023 and most recently revised on 4/1/2024. The trial aims to recruit 30 individuals from a single site."

Answered by AI

Does this research project allow individuals above the age of 40 to participate?

"Prospective participants in this study must be aged between 18 and 55 years. Notably, there are 41 trials dedicated to individuals younger than 18 years old and another 328 studies targeting those above the age of 65."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Targeting the Default Mode Network: A TMS-fMRI Study

Allyson Rosen 2023. "Targeting the Default Mode Network: A TMS-fMRI Study". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05646732.