Proton SBRT for Spinal Cancer
Trial Summary
What is the purpose of this trial?
This is a single-arm pilot study of proton stereotactic body radiotherapy (SBRT) for nonhematologic spinal metastasis in patients with complex lesions that are unable to be effectively treated with standard of care photon SBRT defined as inability to develop a photon SBRT plan that achieves adequate coverage (≥80% planning treatment volume (PTV) coverage)) with a prescription dose of 30 Gy in 5 fractions.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of the treatment Spinal Proton SBRT for spinal cancer?
Is Proton SBRT for spinal cancer safe for humans?
Research shows that high-dose proton therapy, including techniques like pencil beam scanning, has been studied for safety in treating various conditions, including spinal tumors. Studies indicate that it is generally safe, with no severe (Grade 4 or 5) treatment-related toxicities observed, although some mild to moderate side effects may occur.12678
How is Spinal Proton SBRT treatment different from other treatments for spinal cancer?
Spinal Proton SBRT is unique because it uses proton beams, which can be more precisely targeted to the tumor, potentially reducing damage to surrounding healthy tissue compared to traditional radiation therapies. This precision may lead to fewer side effects and improved outcomes for patients with spinal cancer.12349
Research Team
Kristin Redmond, MD
Principal Investigator
Johns Hopkins University
Eligibility Criteria
This trial is for adults with non-blood-related cancer that has spread to the spine, where standard radiation therapy isn't suitable due to complex lesions. Participants need proof of such cancer, spinal metastasis visible on MRI, and must be in a condition allowing daily activities (ECOG ≤2). They should agree to use contraception and understand the study's experimental nature.Inclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive proton stereotactic body radiotherapy (SBRT) for spinal metastasis
Follow-up
Participants are monitored for safety and effectiveness after treatment, including assessments of neurologic toxicity, local control rate, and quality of life
Treatment Details
Interventions
- Spinal Proton SBRT
Find a Clinic Near You
Who Is Running the Clinical Trial?
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Lead Sponsor
Sibley Foundation
Collaborator