Forward to Quit for Smoking Cessation

(F2Q Trial)

Overseen By Christina Sun, PhD

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: University of Colorado, Denver

Must not be taking: Nicotine replacement therapies

Disqualifiers: Medical conditions, Other cessation programs, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests the effectiveness of a new mobile health program called Forward to Quit (F2Q), designed to help transgender adults stop smoking. Transgender individuals and healthcare providers contributed to the program's creation, focusing on easing the quitting process and enhancing overall support. The study will evaluate the program's usability and effectiveness in helping participants quit smoking. Ideal candidates for the trial are transgender individuals who smoke at least five cigarettes a day and are ready to attempt quitting using a smartphone or tablet. As an unphased trial, this study allows participants to contribute to innovative research tailored to their community.

Will I have to stop taking my current medications?

The trial requires that you are not currently using medications for nicotine dependence. If you are, you would need to stop using them to participate.

What prior data suggests that the Forward to Quit (F2Q) intervention is safe for transgender adults?

Research shows that mobile health tools like the Forward to Quit (F2Q) app are generally safe and easy to use. Studies have found that these apps help people quit smoking effectively, with very few side effects. Specifically, a review of multiple studies found that people using online health tools have higher success rates in quitting smoking compared to traditional methods, without major negative effects. Thus, using an app like F2Q is a safe and promising choice for those wanting to quit smoking. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Forward to Quit (F2Q) is unique because it offers a mobile health (mHealth) intervention specifically tailored for transgender adults who are trying to quit smoking. Unlike traditional smoking cessation methods like nicotine replacement therapies or prescription medications, F2Q leverages personalized digital support, making it more accessible and potentially more engaging for its users. Researchers are excited about this treatment because it addresses the specific needs and challenges faced by transgender individuals, aiming to provide a more inclusive and effective approach to smoking cessation.

What evidence suggests that the Forward to Quit intervention is effective for smoking cessation in transgender adults?

Research has shown that mobile health (mHealth) tools can help people quit smoking more effectively than traditional methods. Studies indicate that these digital tools can increase quit rates by about 86% compared to usual methods. mHealth tools, such as text messages or app-based guidance, offer personalized support. Although less information exists on their effectiveness specifically for transgender adults, the Forward to Quit (F2Q) intervention in this trial aims to address this gap. The mHealth approach appears promising due to its adaptability to individual needs. ^{1 2 4 5 6}

Who Is on the Research Team?

Christina Sun, PhD

Principal Investigator

Universtiy of Colorado Anschutz Medical Campus

Are You a Good Fit for This Trial?

This trial is for transgender adults (18+) who smoke at least 5 cigarettes a day, have smoked over 100 in their lifetime, speak English, own an internet-capable device, and are willing to try quitting smoking using a website-based program. Participants must be ready to set a quit date within one month and provide samples to verify quitting.

Inclusion Criteria

I identify with a gender different from my sex at birth.

I am 18 years old or older.

I smoke at least 5 cigarettes daily.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Usability Testing

Participants engage in usability testing of the Forward to Quit (F2Q) mHealth intervention

2-4 weeks

Intervention

Participants receive access to the Forward to Quit (F2Q) mHealth smoking cessation intervention tailored for transgender adults

3 months

Remote participation

Follow-up

Participants are monitored for feasibility, acceptability, and smoking cessation outcomes

3 months post-baseline

What Are the Treatments Tested in This Trial?

Interventions

• Forward to Quit (F2Q)

Trial Overview

The study tests 'Forward to Quit' (F2Q), a mobile health program made with input from transgender people and healthcare providers. It aims to help transgender adults quit smoking through personalized online support. The trial checks if the program is easy and acceptable to use.

How Is the Trial Designed?

Group I: F2Q Intervention Experimental Treatment 1 Intervention

Participants will receive access to the Forward to Quit (F2Q) mHealth smoking cessation intervention tailored for transgender adults

Who Is Running the Clinical Trial?

University of Colorado, Denver

Lead Sponsor

Trials

1,842

Recruited

3,028,000+

National Institute on Drug Abuse (NIDA)

Collaborator

Trials

2,658

Recruited

3,409,000+

Citations

1.

clinicaltrials.gov

clinicaltrials.gov/study/NCT07181551

Study Details | NCT07181551 | Forward to Quit: A Person- ...

Primary outcomes include feasibility and acceptability of both the intervention and remote biochemical verification of smoking cessation. Secondary outcomes ...

2.

pmc.ncbi.nlm.nih.gov

pmc.ncbi.nlm.nih.gov/articles/PMC3809119/

Toward an mHealth Intervention for Smoking Cessation - PMC

The outcome data will also reveal predictors of intention to quit smoking, successful quit attempts, and relapses. Other social cognitive variables that ...

3.

ctv.veeva.com

ctv.veeva.com/study/forward-to-quit-a-person-centered-mobile-technology-intervention-for-smoking-cessation-among-transg

Forward to Quit: A Person-centered Mobile Technology ...

Primary outcomes include feasibility and acceptability of both the intervention and remote biochemical verification of smoking cessation.

4.

mhealth.jmir.org

mhealth.jmir.org/2023/1/e46155

Feasibility, Acceptability, and Potential Impact of a Novel ...

This study aims to assess the feasibility, acceptability, and potential impact of a novel mHealth app for smokers who want to quit smoking someday but are ...

5.

tobaccoinduceddiseases.org

tobaccoinduceddiseases.org/Usage-acceptability-and-preliminary-effectiveness-of-an-nmHealth-based-integrated,156828,0,2.html

Usage, acceptability, and preliminary effectiveness of an ...

The WQ modality could be well used and accepted, and it has great potential to motivate and aid short-term smoking cessation in smokers from western China.

6.

link.springer.com

link.springer.com/article/10.1186/s13011-025-00651-z

Effect and acceptability of an mHealth smoking cessation ...

Smoking cessation interventions tend to be less effective for people of lower socioeconomic position (SEP) compared to those of higher SEP.