Indoor Air Quality Monitor for Smoking Cessation

Recruiting at 7 trial locations

Overseen By Jamie Ostroff, PhD

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Memorial Sloan Kettering Cancer Center

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Approved in 2 Jurisdictions This treatment is already approved in other countries

Compensation: Varies

Number of Visits: 14

Duration: 8 weeks

10 Participants Needed

Trial Summary

What is the purpose of this trial?

The purpose of this study is to evaluate how using an indoor air quality monitor can promote a smoke-free home for cancer patients who are enrolled in MSK's Tobacco Treatment Program.

Do I need to stop taking my current medications for this trial?

The trial information does not specify whether you need to stop taking your current medications. It focuses on using an air quality monitor to help quit smoking, so it's best to ask the trial coordinators for more details.

What data supports the effectiveness of the treatment Indoor Air Quality Monitor AirGradient ONE for smoking cessation?

Research shows that using air quality monitors and air cleaners can help reduce indoor air pollution, which has been linked to better respiratory health. In a study, air cleaners improved symptoms in people with chronic obstructive pulmonary disease (COPD), suggesting that improving indoor air quality might also support smoking cessation efforts by highlighting the impact of smoking on air quality. ^{1 2 3 4 5}

Is the Indoor Air Quality Monitor for Smoking Cessation safe for humans?

The research articles do not provide specific safety data for the Indoor Air Quality Monitor for Smoking Cessation or its related models. However, they discuss the use of air quality monitors in general, which are used to measure indoor air pollution from smoking, and there are no reported safety concerns related to the monitors themselves. ^{3 6 7 8 9}

How does the Indoor Air Quality Monitor for Smoking Cessation differ from other treatments for smoking cessation?

The Indoor Air Quality Monitor for Smoking Cessation is unique because it uses a device to measure carbon monoxide levels in the air, helping individuals track their smoking habits in real-time. Unlike traditional methods that rely on self-reporting or standalone devices, this approach provides continuous, objective feedback, potentially increasing awareness and motivation to quit smoking. ^{10 11 12 13 14}

Research Team

Jamie Ostroff, PhD

Principal Investigator

Memorial Sloan Kettering Cancer Center

Eligibility Criteria

This trial is for cancer patients trying to quit smoking and are enrolled in MSK's Tobacco Treatment Program. It aims to see if using an air quality monitor helps them keep their homes smoke-free.

Inclusion Criteria

Has been referred and enrolled in the MSK TTP and completed the initial counseling session as per the TTP clinical database

Reports current (within the past 30 days) tobacco use (i.e., cigarettes and/or any other tobacco products) as per the TTP Intake form

I am over 18 years old.

Exclusion Criteria

N/A

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants use an indoor air quality monitor and attend smoke-free workshop sessions

8 weeks

Participants use the device for 14 consecutive days and attend workshops

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

Treatment Details

Interventions

• Indoor Air Quality Monitor AirGradient ONE

Trial Overview The study is testing the effectiveness of the AirGradient ONE indoor air quality monitor in encouraging a smoke-free environment at home among participants.

Participant Groups

Group I: MSK Participants who are current smokers Experimental Treatment 1 Intervention

10 MSK participants who are current smokers and receiving tobacco treatment will be enrolled.

Who Is Running the Clinical Trial?

Memorial Sloan Kettering Cancer Center

Lead Sponsor

Trials

1,998

Recruited

602,000+

Findings from Research

The use of active portable high-efficiency particulate air cleaners showed a significant reduction in respiratory symptoms and moderate exacerbations in former smokers with COPD over a 6-month period, indicating potential health benefits from reducing indoor particulate matter.

Participants who adhered to using the air cleaners and spent more time indoors experienced greater improvements in their respiratory health, suggesting that these devices could be particularly effective for individuals with COPD in indoor environments.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Randomized Clinical Trial of Air Cleaners to Improve Indoor Air Quality and Chronic Obstructive Pulmonary Disease Health: Results of the CLEAN AIR Study. Hansel, NN., Putcha, N., Woo, H., et al.[2023]

In a 6-month study involving 116 former smokers with COPD, 76.1% of participants adhered to using portable air cleaners at least 80% of the time, which could potentially improve their respiratory health by reducing indoor pollutants.

Factors such as higher household income and using electric heating were linked to better adherence, while lower quality of life and recent exacerbations were associated with lower adherence, indicating that socioeconomic and health status play crucial roles in the effectiveness of air cleaner interventions.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Patterns and Predictors of Air Cleaner Adherence Among Adults with COPD. Lorizio, W., Woo, H., McCormack, MC., et al.[2022]

The study involved 39 pregnant women who smoke, and qualitative interviews revealed that while many wanted to change their smoking behaviors, external factors like living with other smokers often hindered their commitment to quitting.

Although indoor air quality (IAQ) measurements did not significantly improve overall quit rates, they did help some women modify their smoking behaviors, suggesting that this approach could be beneficial in supporting smoking cessation efforts during pregnancy.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

An interview study of pregnant women who were provided with indoor air quality measurements of second hand smoke to help them quit smoking. Morgan, H., Treasure, E., Tabib, M., et al.[2021]

In a randomized controlled trial involving 126 children with asthma living with smokers, the use of air cleaners significantly reduced indoor particulate matter (PM) concentrations and increased symptom-free days compared to a control group without air cleaners.

However, the intervention did not significantly lower air nicotine or urine cotinine levels, indicating that while air cleaners help improve air quality, they are not sufficient to completely eliminate secondhand smoke exposure.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

A randomized trial of air cleaners and a health coach to improve indoor air quality for inner-city children with asthma and secondhand smoke exposure. Butz, AM., Matsui, EC., Breysse, P., et al.[2021]

The Beijing Indoor Air Purifier Study (BIAPSY) demonstrated that active air filtration significantly reduced indoor air pollutants, including PM2.5 and black carbon, improving air quality in homes over a two-week period.

Despite the improvements in air quality, the study found no significant changes in lung function, blood pressure, or heart rate variability among participants, indicating that while air filtration is effective for reducing pollutants, it may not lead to immediate cardio-respiratory health benefits.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Cardiorespiratory responses of air filtration: A randomized crossover intervention trial in seniors living in Beijing: Beijing Indoor Air Purifier StudY, BIAPSY. Shao, D., Du, Y., Liu, S., et al.[2019]

The Novel Tobacco Vapor (NTV) product was found to produce emissions that are chemically simpler than traditional cigarette smoke, indicating a potentially less harmful alternative.

In controlled simulations of both non-smoking and smoking environments, the use of the NTV product did not significantly affect indoor air quality, with no measurable increases in harmful substances like formaldehyde or ammonia.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Indoor air quality (IAQ) evaluation of a Novel Tobacco Vapor (NTV) product. Ichitsubo, H., Kotaki, M.[2023]

In a pilot study with 29 smoking families, real-time feedback from air quality monitors (like the Dylos) was effective in providing clear information about tobacco smoke air pollution (TSAP) levels, which could encourage parents to create smoke-free homes.

Continuous monitoring of PM(2.5) levels was less effective due to noise and misleading peaks from non-smoking sources, highlighting the need for improved measurement techniques and real-time feedback systems to better protect children from tobacco smoke exposure.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Feasibility of Measuring Tobacco Smoke Air Pollution in Homes: Report from a Pilot Study. Rosen, L., Zucker, D., Hovell, M., et al.[2018]

A new portable internet-connected air quality monitor was developed and tested in eight homes in Israel, showing less than 1% data loss and reliable real-time monitoring of secondhand smoke exposure.

The remote monitoring system provided data comparable to traditional methods, indicating it could effectively support interventions aimed at reducing secondhand smoke in homes, particularly benefiting children's health.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Monitoring secondhand tobacco smoke remotely in real-time: A simple low-cost approach. Dobson, R., Rosen, LJ., Semple, S.[2023]

Heat-not-burn (HnB) products emit lower levels of nicotine (0.8-1.2 mg per cigarette) compared to conventional cigarettes (2.4-3.6 mg per cigarette), suggesting a potential reduction in nicotine exposure for users.

However, HnB products release higher levels of vegetable glycerin (3.1-5.9 mg per cigarette) than conventional cigarettes, and they still produce various volatile organic compounds (VOCs), aldehydes, nanoparticles, and particulate matter, which negatively impact indoor air quality.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Preliminary study on the effect of using heat-not-burn tobacco products on indoor air quality. Yu, SJ., Kwon, MK., Choi, W., et al.[2022]

The mobile-phone-based Breath CO meter prototype demonstrated a strong correlation with a commercial Breath CO meter (r = .96), indicating its reliability and validity for measuring carbon monoxide levels in breath.

Participants found the mobile meter acceptable and expressed interest in using it for smoking cessation, suggesting it could be a valuable tool for supporting quit attempts.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

A mobile-phone-based breath carbon monoxide meter to detect cigarette smoking. Meredith, SE., Robinson, A., Erb, P., et al.[2023]

The Personal Automatic Cigarette Tracker (PACT) is a new wearable sensor system that accurately monitors smoking behavior without requiring conscious effort from the user, tested on 20 individuals performing various activities.

The system detects unique breathing patterns associated with smoking, which can help identify individual smoke inhalations and potentially improve the assessment of smoking interventions in real-world settings.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

A wearable sensor system for monitoring cigarette smoking. Sazonov, E., Lopez-Meyer, P., Tiffany, S.[2021]

The smartphone-enabled iCO monitor consistently provided higher carbon monoxide (CO) readings compared to the Micro+ pro and Micro+ basic monitors, indicating that different devices yield different results.

To accurately determine smoking abstinence, specific CO cutoff values are necessary: <3 ppm for the Micro+ monitors and <6 ppm for the iCO monitor, highlighting the importance of using the correct device-specific thresholds for bioverification.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Mobile, Remote, and Individual Focused: Comparing Breath Carbon Monoxide Readings and Abstinence Between Smartphone-Enabled and Stand-Alone Monitors. Tuck, BM., Karelitz, JL., Tomko, RL., et al.[2021]

The study found that the Bedfont piCO+ Smokerlyzer consistently reported higher expired-air carbon monoxide (CO) levels than the Vitalograph BreathCO, with an average difference of 3.83 ppm, indicating a lack of agreement between the two monitors.

This discrepancy in CO measurements suggests that the choice of monitor can significantly affect the classification of smoking abstinence, which is crucial for smoking research and treatment outcomes.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

ANALYSIS OF AGREEMENT BETWEEN EXPIRED-AIR CARBON MONOXIDE MONITORS. Karelitz, JL., Michael, VC., Perkins, KA.[2022]

The Bedfont EC50 is a new, portable, and inexpensive analyzer for measuring expired-air carbon monoxide, which has shown good correlation with standard measurement methods in a study of 138 normal subjects.

This new analyzer is more effective at accurately identifying smoking status compared to traditional methods, making it a valuable tool for both field and clinical settings.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Evaluation of a portable measure of expired-air carbon monoxide. Irving, JM., Clark, EC., Crombie, IK., et al.[2019]

References

1. United States pubmed.ncbi.nlm.nih.gov

Randomized Clinical Trial of Air Cleaners to Improve Indoor Air Quality and Chronic Obstructive Pulmonary Disease Health: Results of the CLEAN AIR Study. [2023]

2. United States pubmed.ncbi.nlm.nih.gov

Patterns and Predictors of Air Cleaner Adherence Among Adults with COPD. [2022]

3. England pubmed.ncbi.nlm.nih.gov

An interview study of pregnant women who were provided with indoor air quality measurements of second hand smoke to help them quit smoking. [2021]

4. United States pubmed.ncbi.nlm.nih.gov

A randomized trial of air cleaners and a health coach to improve indoor air quality for inner-city children with asthma and secondhand smoke exposure. [2021]

5. Netherlands pubmed.ncbi.nlm.nih.gov

Cardiorespiratory responses of air filtration: A randomized crossover intervention trial in seniors living in Beijing: Beijing Indoor Air Purifier StudY, BIAPSY. [2019]

6. Netherlands pubmed.ncbi.nlm.nih.gov

Indoor air quality (IAQ) evaluation of a Novel Tobacco Vapor (NTV) product. [2023]

7. Switzerland pubmed.ncbi.nlm.nih.gov

Feasibility of Measuring Tobacco Smoke Air Pollution in Homes: Report from a Pilot Study. [2018]

8. Greece pubmed.ncbi.nlm.nih.gov

Monitoring secondhand tobacco smoke remotely in real-time: A simple low-cost approach. [2023]

9. Netherlands pubmed.ncbi.nlm.nih.gov

Preliminary study on the effect of using heat-not-burn tobacco products on indoor air quality. [2022]

10. England pubmed.ncbi.nlm.nih.gov

A mobile-phone-based breath carbon monoxide meter to detect cigarette smoking. [2023]

11. United States pubmed.ncbi.nlm.nih.gov

A wearable sensor system for monitoring cigarette smoking. [2021]

12. England pubmed.ncbi.nlm.nih.gov

Mobile, Remote, and Individual Focused: Comparing Breath Carbon Monoxide Readings and Abstinence Between Smartphone-Enabled and Stand-Alone Monitors. [2021]

13. England pubmed.ncbi.nlm.nih.gov

ANALYSIS OF AGREEMENT BETWEEN EXPIRED-AIR CARBON MONOXIDE MONITORS. [2022]

14. United States pubmed.ncbi.nlm.nih.gov

Evaluation of a portable measure of expired-air carbon monoxide. [2019]