Mobile Enhanced Prevention Support for HIV Prevention and Substance Use Disorder
What You Need to Know Before You Apply
What is the purpose of this trial?
The California Hub for HIV/SUD Prevention Research with Reentry Populations addresses the question: "Can the evidence-based MEPS intervention be adapted and implemented at a range of organizations to effectively serve a wider range of clients?"
The Mobile Enhanced Prevention Support (MEPS) intervention was originally implemented in Los Angeles County and was proven successful in promoting biomedical HIV prevention (PrEP) uptake and preventative screenings in people who used drugs who recently left incarceration. MEPS is an evidence-based intervention for people with substance use disorders (SUD) that incorporates a client-centered planning session, including trained peer mentors, service utilization incentives, and a mobile application (GeoPass).
The study includes a randomized controlled trial (RCT) across three community partners located in Riverside and Alameda Counties. At least 300 people will be enrolled in these three counties; the first 200 will be randomized to either receive the intervention or usual care, with the final 100 all receiving the intervention. The primary implementation outcome for the study involves using an implementation science framework and assessment tools to examine MEPS's implementation. Key outcomes include how well the implementation strategies used support intervention enrollment and retention, integration with existing services in each partnering community agency, and perceived intervention acceptability, feasibility, appropriateness, and maintenance at 6- and 12-months. The primary effectiveness outcome for the study is an increase in HIV testing, PrEP uptake and adherence, and SUD service utilization at 6 months and 12 months in the MEPS compared to the usual care group. Secondary effectiveness outcomes include frequency of service use for SUDs, hepatitis C virus testing, and linkage to care for those who test positive for HIV or hepatitis C.
Are You a Good Fit for This Trial?
Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Client-centered Planning Session
All participants receive a client-centered planning session following enrollment, conducted by phone, video, or in person.
Treatment
Participants in the intervention arm receive the MEPS intervention, including 14 sessions with a peer mentor over 6 months, cash incentives, and use of the GeoPass app.
Follow-up
Participants are monitored for effectiveness and adherence to PrEP, HIV testing, and SUD service utilization at 6 and 12 months.
What Are the Treatments Tested in This Trial?
Interventions
- Mobile Enhanced Prevention Support (MEPS)
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Intervention arm participants receive a client-centered goal planning session following enrollment; 14 sessions with a peer mentor over a period of 6 months; cash incentives for accessing medical and non-medical services; and a smartphone app to keep track of goals, incentive earnings and provider appointments, a provider search feature, and fill-out surveys based on participant experiences with accessing services.
Control arm participants receive a client-centered goal planning session (like the intervention arm), and usual care.
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, Los Angeles
Lead Sponsor
National Institute on Drug Abuse (NIDA)
Collaborator
University of California, Berkeley
Collaborator
Charles Drew University of Medicine and Science
Collaborator
Starting Over, Inc
Collaborator
Kindful Restoration
Collaborator
CAL-PEP
Collaborator
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