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SCORES (Specific COgnitive Remediation with Support) for Schizophrenia Prodromal

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Schizophrenia Prodromal+2 MoreSCORES (Specific COgnitive Remediation with Support) - Behavioral
Eligibility
14 - 20
All Sexes
What conditions do you have?
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Study Summary

This trial intervention is designed to help those at risk for schizophrenia by targeting processing speed, which is directly related to social functioning. The exercises and group support in the intervention are meant to improve motivation and engagement in adolescents.

Eligible Conditions
  • Schizophrenia Prodromal
  • Psychosis
  • Prodromal Symptoms

Treatment Effectiveness

Effectiveness Progress

1 of 3

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CREADY (Cognitive-Remediation of Executive and Adaptive Deficits in Youth)
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Study Objectives

1 Primary · 2 Secondary · Reporting Duration: Baseline, Mid-Treatment (5 weeks), Post Treatment (10 weeks)

Week 10
Global Functioning: Social (GF:Social) scale (Phase 2/R33 only)
Processing Speed domain score from the MATRICS Consensus Cognitive Battery (MCCB)
SIPS/SOPS: Positive Symptoms (Phase 2/R33 only)

Trial Safety

Safety Progress

1 of 3

Similar Trials

2
CREADY (Cognitive-Remediation of Executive and Adaptive Deficits in Youth)
2
Donepezil + Cognitive remediation therapy (CRT)
2
Voxelotor

Trial Design

1 Treatment Group

Single Arm intervention
1 of 1

Experimental Treatment

30 Total Participants · 1 Treatment Group

Primary Treatment: SCORES (Specific COgnitive Remediation with Support) · No Placebo Group · N/A

Single Arm intervention
Behavioral
Experimental Group · 1 Intervention: SCORES (Specific COgnitive Remediation with Support) · Intervention Types: Behavioral

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: baseline, mid-treatment (5 weeks), post treatment (10 weeks)

Who is running the clinical trial?

Northwell HealthLead Sponsor
425 Previous Clinical Trials
493,500 Total Patients Enrolled
2 Trials studying Schizophrenia Prodromal
38 Patients Enrolled for Schizophrenia Prodromal
National Institute of Mental Health (NIMH)NIH
2,560 Previous Clinical Trials
1,823,811 Total Patients Enrolled
2 Trials studying Schizophrenia Prodromal
325 Patients Enrolled for Schizophrenia Prodromal
Barbara A Cornblatt, Ph.D.Principal InvestigatorNorthwell Health

Eligibility Criteria

Age 14 - 20 · All Participants · 2 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You have a structured interview for psychosis risk syndromes, defined by the presence of at least one attenuated positive symptom at a moderate to severe level.
References

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