Wound Closure Methods for Scar Appearance
Trial Summary
Do I need to stop taking my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of the treatment Intra-dermal purse-string closure, Transcutaneous purse-string closure for scar appearance?
Research shows that the purse-string suture technique, which is similar to the treatments being studied, can effectively close skin wounds with minimal scarring. It has been used successfully to reduce the size of scars and improve healing in various types of skin defects, including those from tumor excisions.12345
Is the purse-string suture method safe for wound closure in humans?
The purse-string suture method has been used in humans for closing skin defects with minimal scarring, and it is generally considered safe. In a study involving 196 patients, complications were relatively low, with 10.4% experiencing wound reopening, often due to poor skin quality or using too small sutures. Overall, patient satisfaction with the results is high, especially for large facial excisions.12456
How does the purse-string suture treatment differ from other treatments for wound closure?
The purse-string suture treatment is unique because it can reduce the size of circular or oval wounds, potentially minimizing scarring and the need for skin grafts. It offers versatility by being applicable to various wound sizes and locations, and it can be used when linear closure is not possible, maintaining local tissue architecture.12347
What is the purpose of this trial?
The purpose of this study is to determine whether intra-dermal versus transcutaneous purse-string closures have similar scar cosmesis and post-operative complications. The investigators will use a split wound model, where half of the wound will be closed with intra-dermal purse-string sutures and the other half will be closed with a transcutaneous purse-string sutures. Three-months post-surgery, the scar will be evaluated via the patient observer scar assessment scale (POSAS), a validated scar instrument, as well as the trace-to-tape method, an objective outcome measure for linear postoperative scars. Any adverse events will also be recorded.
Research Team
Daniel Eisen, MD
Principal Investigator
University of California, Davis - Dermatology
Eligibility Criteria
This trial is for individuals with scars who are undergoing surgery that requires wound closure. The study will compare two different stitching techniques to see which results in better-looking scars and fewer complications.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo surgery with split-wound model using intra-dermal and transcutaneous purse-string closures
Follow-up
Participants are monitored for scar assessment and post-operative complications using POSAS and Trace-to-Tape methods
Treatment Details
Interventions
- Intra-dermal purse-string closure
- Transcutaneous purse-string closure
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of California, Davis
Lead Sponsor