Prebiotic Sodas for Satiety

Overseen By Senior Scientist

Age: 18 - 65

Sex: Any

Trial Phase: Academic

Sponsor: Olipop, PBC

Must not be taking: GLP-1 RAs, Warfarin, Antibiotics, others

Disqualifiers: Pregnancy, Diabetes, Liver disease, others

Compensation: Varies

Number of Visits: 4

Duration: 4-12 weeks

15 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

The main objective of this study is to evaluate the acute effects of prebiotic sodas on postprandial levels of glucagon-like peptide-1 (GLP-1), peptide YY (PYY), gastric emptying, and satiety levels in healthy adults.

Who Is on the Research Team?

Janice Campbell

Principal Investigator

INQUIS Clinical Research

Are You a Good Fit for This Trial?

This trial is for healthy adults interested in the effects of prebiotic sodas on digestion and feelings of fullness after eating. Specific eligibility criteria are not provided, but typically participants should not have conditions affecting metabolism or digestive health.

Inclusion Criteria

Understanding the study procedures and willing to provide informed consent to participate in the study and authorization to release relevant protected health information to the study investigator

Subjects must be eligible to receive income in Canada and be covered by a health insurance plan such as Ontario Health Insurance Plan (OHIP)

BMI between 18.0 and 30.0 kg/m2

Exclusion Criteria

Subjects with a history of severe food allergies or an allergy to acetaminophen

Self-reported pregnant or breastfeeding women

Known history of diabetes, any gastrointestinal disorder that alters the absorption of nutrients, liver disease, or the presence of any health condition, illness, or drug use that increases risk to the subject or to others or may affect the results, as judged by the Qualified Investigator (QI)

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Treatment

Participants consume a single dose of 3 different prebiotic sodas and one control soda in a randomized, crossover design

4-12 weeks

4 visits (in-person)

Follow-up

Participants are monitored for postprandial levels of GLP-1, PYY, gastric emptying, and satiety levels

2 hours post each intervention

What Are the Treatments Tested in This Trial?

Interventions

• Prebiotic Soda

Trial Overview

The study tests how different types of prebiotic sodas (refrigerated, shelf stable, and with an added functional ingredient) affect hormone levels related to hunger and digestion speed compared to a control soda without prebiotics.

How Is the Trial Designed?

Group I: Prebiotic Soda - Shelf Stable + Functional Ingredient Experimental Treatment 1 Intervention

Participants will consume one 12 oz can of the shelf stable prebiotic soda with an added functional ingredient

Group II: Prebiotic Soda - Shelf Stable Experimental Treatment 1 Intervention

Participants will consume one 12 oz can of the shelf stable prebiotic soda

Group III: Prebiotic Soda - Refrigerated Experimental Treatment 1 Intervention

Participants will consume one 12 oz can of the refrigerated prebiotic soda

Group IV: Control Soda Placebo Group 1 Intervention

Participants will consume one 12 oz can of a control soda

Who Is Running the Clinical Trial?

Olipop, PBC

Lead Sponsor

Trials

1

Recruited

30+

INQUIS Clinical Research

Industry Sponsor

Trials

12

Recruited

400+