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Proton Beam Therapy

Proton Radiation for Pediatric Sarcoma

N/A

Waitlist Available

Led By Torunn Yock, MD

Research Sponsored by Massachusetts General Hospital

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Biopsy proven NRSTS or bone sarcoma

Patients must have been treated with a standardly accepted chemotherapy regimen if chemotherapy is indicated

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 5 years

Awards & highlights

Study Summary

This trial will study the effects of proton beam radiation on children with bone or non-rhabdomyosarcoma soft tissue sarcomas.

Who is the study for?

This trial is for children and young adults up to 30 years old with bone sarcoma or non-rhabdomyosarcoma soft tissue sarcomas. They must have had standard chemotherapy if needed, agree to long-term follow-up at MGH, and provide informed consent. Pregnant individuals, those planning certain chemotherapies, or with conditions making radiation unsafe are excluded.Check my eligibility

What is being tested?

The study is examining the effects of proton beam radiation therapy on pediatric patients with specific types of sarcomas. It aims to understand both immediate and long-term side effects from this treatment over a minimum five-year follow-up period.See study design

What are the potential side effects?

While not explicitly listed in the provided information, common side effects of proton beam radiation may include skin reactions at the treatment site, fatigue, hair loss near treated areas, and potential damage to nearby healthy tissues.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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My cancer is a non-rhabdomyosarcoma soft tissue sarcoma or bone sarcoma, confirmed by biopsy.

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I have received standard chemotherapy if it was recommended for my condition.

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I am 30 years old or younger.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 5 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~5 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Acute and late toxicities

Local Control

Secondary outcome measures

Dosimetric Comparison

Side effects data

From 2017 Phase 1 & 2 trial • 50 Patients • NCT00438256

100%

Fatigue

100%

Nausea

67%

Vomiting

67%

Abdomen- pain

33%

Anorexia

33%

Dehydration

33%

Constipation

33%

Bilirubin

100%

80%

60%

40%

20%

Study treatment Arm

Proton Beam Radiation/ Capecitabine Dose Level 1

Proton Beam Radiation/ Capecitabine Dose Level 3

Proton Beam Radiation/ Capecitabine Dose Level 4

Proton Beam Radiation/ Capecitabine Dose Level 2

Trial Design

1Treatment groups

Experimental Treatment

Group I: Proton Beam RadiationExperimental Treatment1 Intervention

Proton Beam Radiation

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Proton Beam Radiation

2007

Completed Phase 2

~70

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

National Institutes of Health (NIH)NIH

2,696 Previous Clinical Trials

6,952,518 Total Patients Enrolled

Massachusetts General HospitalLead Sponsor

2,928 Previous Clinical Trials

13,198,285 Total Patients Enrolled

Brigham and Women's HospitalOTHER

1,608 Previous Clinical Trials

11,469,807 Total Patients Enrolled

Media Library

Proton Beam Radiation (Proton Beam Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT00592293 — N/A

Proton Beam Radiation (Proton Beam Therapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT00592293 — N/A

Soft Tissue Sarcomas Research Study Groups: Proton Beam Radiation

Soft Tissue Sarcomas Clinical Trial 2023: Proton Beam Radiation Highlights & Side Effects. Trial Name: NCT00592293 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is enrollment still available for this clinical experiment?

"Looking at the clinicaltrials.gov website, it appears that this trial is no longer accepting patients. Although first posted on October 1st 2006 and last modified on September 30th 2021, 445 other trials are actively recruiting as of right now."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Proton Radiation for the Treatment of Pediatric Bone and Non-Rhabdomyosarcoma Soft Tissue Sarcomas

Torunn Yock, MD 2006. "Proton Radiation for the Treatment of Pediatric Bone and Non-Rhabdomyosarcoma Soft Tissue Sarcomas". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT00592293.

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