Pain Processing for Fibromyalgia and Rheumatoid Arthritis
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to understand how pain functions differently in people with fibromyalgia, a condition causing widespread pain, and rheumatoid arthritis, an inflammatory joint disorder. Researchers study how these conditions cause pain to better target treatments. Individuals diagnosed with fibromyalgia or rheumatoid arthritis who experience regular pain might be suitable for this study. Healthy volunteers without significant pain or fatigue are also needed.
As an unphased study, this trial offers a unique opportunity to contribute to groundbreaking research that could lead to more effective pain management strategies.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that this pain processing evaluation is safe for fibromyalgia and rheumatoid arthritis patients?
Research shows that pain processing evaluation, used to study fibromyalgia and rheumatoid arthritis, helps researchers understand how the body interprets pain signals. So far, no studies have shown safety issues with this type of evaluation.
In these studies, patients with fibromyalgia and rheumatoid arthritis underwent assessments using tools that measure pain intensity and response. While this is not a treatment but a method to assess pain, it is important to note that no serious side effects have been reported from similar evaluations. This indicates that the evaluation is generally well-tolerated by patients.
For those considering joining a trial involving pain processing evaluation, current evidence suggests it is safe to participate. However, as with any study, discussing any concerns with the trial team or a doctor is advisable.12345Why are researchers excited about this trial?
Researchers are excited about the Pain Processing Evaluation because it takes a fresh approach to understanding chronic pain conditions. Unlike standard treatments that often focus on symptom management with medications like NSAIDs or opioids, this method aims to delve into the underlying mechanisms of pain processing. By investigating both inflammatory and non-inflammatory pain pathways, this evaluation could lead to more targeted and effective therapies. The potential to uncover new insights into how chronic pain is processed in the body sets this approach apart from current options and could revolutionize future treatments.
What evidence suggests that this pain processing evaluation is effective for fibromyalgia and rheumatoid arthritis?
Research shows that fibromyalgia (FM) involves changes in how the brain processes pain, known as nociplastic pain. This differs from rheumatoid arthritis (RA), where pain arises from inflamed tissues, referred to as nociceptive pain. Studies have found that people with RA often experience pain similar to FM. Specifically, one study found that 34% of RA patients reported high levels of pain even years after diagnosis. This suggests that FM and RA might share similar pain-processing pathways. Understanding these shared pathways could lead to better treatments for both conditions.36789
Who Is on the Research Team?
Roland Staud, M.D.
Principal Investigator
University of Florida
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Assessment
Pressure pain thresholds are measured using an algometer at the upper and lower extremities
Follow-up
Participants are monitored for safety and effectiveness after assessment
What Are the Treatments Tested in This Trial?
Interventions
- Pain Processing Evaluation
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Florida
Lead Sponsor
Citations
The Prevalence of Fibromyalgia in Rheumatoid Arthritis ...
RA activity measured by DAS 28-ESR showed that 40.2% (N=39) had high disease activity, 38.1% (N=37) had moderate disease activity, 11.3% (N=11) ...
Fibromyalgia and Centralized Pain in the Rheumatoid Arthritis ...
Lastly, using data from an early RA inception cohort that 34% of patients reported unacceptable pain (UP) 5 years after inclusion. Predictors included lower SJC ...
3.
arthritis-research.biomedcentral.com
arthritis-research.biomedcentral.com/articles/10.1186/s13075-022-02903-wDefining the relationship between pain intensity and disease ...
A total of 1132 patients were studied: 490 had early active RA, 469 had established active RA and 173 were in remission/low disease activity.
Pain Processing in Inflammatory and ... - Clinical Trial Finder
The evaluation of pain mechanisms in FM has shown predominant central abnormalities and therefore has been designated as nociplastic pain syndrome.
Quality of rheumatology care for patients with fibromyalgia ...
Results 79 charts were identified. Following consultation, 81% of patients (n=64) maintained the same diagnosis of FM/CP, 19% (n=15) were ...
Fibromyalgia Assessment Tools: Diagnosis & Severity
Pain severity ratings from the 18 tender points are averaged to yield a Fibromyalgia Intensity Score (FIS) that varies from 0 to 10 with higher scores ...
Evaluation of Fibromyalgia Syndrome and Its Effect on ...
This study, it was aimed to evaluate the effect of secondary fibromyalgia syndrome, which is frequently found in rheumatoid arthritis and characterized by ...
Fibromyalgia: Diagnosis and Management
Fibromyalgia is a chronic, centralized pain syndrome characterized by disordered processing of painful stimuli. Fibromyalgia is diagnosed more frequently in ...
The diagnosis of fibromyalgia syndrome
Patients with FMS may not report widespread pain, instead reporting only focal pain. It is, therefore, important to directly ask about the presence of pain ...
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