This trial is evaluating whether Cardiopulmonary rehabilitation post lung transplant will improve 1 primary outcome, 1 secondary outcome, and 2 other outcomes in patients with Respiratory Aspiration. Measurement will happen over the course of 12 weeks.
This trial requires 30 total participants across 2 different treatment groups
This trial involves 2 different treatments. Cardiopulmonary Rehabilitation Post Lung Transplant is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are not being studied for commercial purposes.
The following signs (in summary, ordered by frequency) can be used to highlight specific areas for which clinicians and caregivers need to be educated and trained as to their signs and symptoms:\n\n- Drooling\n- Rapid wheezing\n- Coughing up blood\n- Mucus\n- Fever\n- Lethargy\n- Vomiting\n\nSigns are often related through their shared underlying pathophysiology.
The treatment of respiratory aspiration is based on the specific cause. Nonopioid analgesics, in particular, aspirin, are commonly prescribed for those children with gastroesophageal reflux disease who present with air entry into the trachea. Children hospitalized with respiratory aspiration usually receive antipyretic drugs for the primary treatment, such as ibuprofen and amoxicillin/clavulanic acid for children hospitalized with viral pneumonia. Those children with respiratory aspiration secondary to gastroesophageal reflux disease or foreign objects (e.g., coins, glass chips, popcorn grains) may be treated with an H2RA, such as ranitidine.
Respiratory aspiration is not curable because [its natural history is far from being completely understood] and more will be needed before effective interventions can be developed to prevent aspiration. However, in this light, patients with respiratory distress as a result of aspiration should be screened, managed and monitored with caution.
Aspiration is an issue in children. The number of potential contributing factors is far too many to consider. It is, therefore, more useful to consider the specific child; the environment in which the child is educated and cared for: as a potential contributing factor to aspiration. A full history, examination and appropriate investigation is required.
Respiratory aspiration is a condition in which a food bolus slides down the esophagus and enters the submandibular space, ending up in blood vessels around the tongue and gums. There can be serious consequences including pneumomediastinum, subcutaneous emphysema and airway obstruction.
A significant number of adults have experienced an episode of respiratory aspiration at some point. This is even more likely among seniors. The increased rates of asthma and COPD over time have been linked to the increase in respiratory aspiration.
Consideration by patients or their families is necessary for enrollment in these trials. Clinicians should counsel patients on the risks and benefits of enrollment in these trials.
Respiratory aspiration is a serious medical condition that can lead to death. It most commonly occurs due to eating food or liquids that contain foreign objects, such as a peanut or food from a candy dispenser. Younger people, men, and those with a chronic illness and/or disability are more likely to get respiratory aspiration. When eating, eat quickly and put food into one's mouth so it does not settle on the back of the throat. If someone eats food without pushing it down the throat, food falls into the airway. As food is swallowed, fluid in the food comes along with it. The fluid also settles and blocks the airway, leading to a breathing problem.
Patient safety depends upon the patient's specific health conditions, the clinical area of medical practice and the provider. Therefore, patients with health services associated with respiratory aspiration are at particular risk from adverse effects of inhaled agents. Respiratory aspiration prevention depends on education. More studies with a large sample size are needed to determine whether it is safe and the most appropriate method for prevention.
Data from a recent study found that two common side effects of cardiopulmonary rehabilitation are reduced breathing effort and the transient onset of a sense of dizziness. Both of these are found to be transient and are not directly linked to any of the treatment given in this study. Data from a recent study of this study do not preclude those who are undergoing cardiopulmonary rehabilitation to experience some of these common side effects. This information will allow clinicians to manage these people more efficiently and competently.
A structured, standardized program incorporating aerobic exercise and psychosocial components can significantly increase quality of life for the lung transplant recipient and improve survivability of the transplanted lungs.
Patients with neuromuscular disease, including muscular dystrophy, are at very high risk for accidental aspiration of food and drinks. Patients are frequently given prophylactic medications against aspiration, but these agents fail to prevent all instances of aspiration. We hypothesize that patients require intensive therapy to avoid aspiration.