Genomic Predictors for Miscarriage
(GPRPL Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to understand the genetic factors that might lead to recurrent pregnancy loss (RPL). Researchers seek to identify specific genes or DNA patterns that could help predict the likelihood of experiencing RPL. Women who have lost a pregnancy before 20 weeks and have had at least one other pregnancy loss might be suitable for this study. The goal is to discover new ways to prevent RPL by studying the genetics of those affected.
As an unphased study, this trial offers participants the chance to contribute to groundbreaking research that could lead to future prevention strategies for RPL.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Why are researchers excited about this trial?
Researchers are excited about this trial because it aims to uncover the genomic predictors of recurrent pregnancy loss, a condition with limited understanding and treatment options. Unlike current approaches that mainly address lifestyle factors or hormonal treatments, this research dives into the genetics behind the condition, potentially offering new insights into causes and personalized prevention strategies. By identifying specific genetic markers, this study could pave the way for targeted therapies and improved outcomes for those experiencing recurrent pregnancy loss.
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Sample Collection
Collection of DNA samples from trios (POC, biological mother, and biological father) and potentially other family members
Whole Genome Sequencing
Whole genome sequencing and bioinformatic analyses to identify pathogenic variants
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- None
Find a Clinic Near You
Who Is Running the Clinical Trial?
Yale University
Lead Sponsor
The University of Texas Health Science Center at San Antonio
Collaborator
Wayne State University
Collaborator
University of Oklahoma
Collaborator
Columbia University
Collaborator
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Collaborator
Northwestern University
Collaborator
University of Chicago
Collaborator
University of Colorado, Denver
Collaborator
Augusta University
Collaborator