ECT for Dementia
(ECT-AD Trial)
Trial Summary
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. However, since the study involves ECT plus usual care, it might be possible to continue your current treatments. Please consult with the trial coordinators for specific guidance.
What data supports the effectiveness of the treatment Electroconvulsive Therapy (ECT) for dementia?
Research suggests that Electroconvulsive Therapy (ECT) can be effective and safe for improving symptoms in patients with dementia, especially when they also have depression or severe behavioral issues. Some studies have shown that ECT helps with depression and aggression in dementia patients, although there are concerns about its effects on memory and thinking skills.12345
Is Electroconvulsive Therapy (ECT) safe for treating dementia-related symptoms?
How is electroconvulsive therapy (ECT) different from other treatments for dementia?
Electroconvulsive therapy (ECT) is unique because it uses electrical currents to induce controlled seizures, which can improve symptoms of depression and behavioral issues in dementia patients, especially when other treatments are ineffective. Unlike medications, ECT can be effective for severe cases and offers a different approach by directly affecting brain activity.12345
What is the purpose of this trial?
This study will explore the effect of ECT treatments plus usual care (ECT+UC) in reducing severe agitation in patients with moderate to severe dementia including Alzheimer's Disease, Vascular dementia, Frontotemporal dementia, and Dementia with Lewy Bodies. The study will also determine the tolerability/safety outcomes of ECT+UC.
Research Team
Brent P Forester, MD
Principal Investigator
Mclean Hospital
George Petrides, MD
Principal Investigator
Northwell Health
Eligibility Criteria
This trial is for people aged 40+ with moderate to severe dementia, including Alzheimer's, who show severe agitation. They must have tried at least one medication that didn't work and be medically stable for ECT. Those with certain psychiatric disorders, active substance use disorder, or recent neurostimulation therapy can't join.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive Electroconvulsive Therapy (ECT) plus usual care for severe agitation in dementia
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Electroconvulsive Therapy (ECT)
- Simulated Electroconvulsive Therapy (S-ECT)
Electroconvulsive Therapy (ECT) is already approved in United States, European Union, Canada for the following indications:
- Severe depression
- Bipolar disorder
- Schizophrenia
- Catatonia
- Agitation in dementia (off-label)
- Severe depression
- Bipolar disorder
- Schizophrenia
- Catatonia
- Agitation in dementia (off-label)
- Severe depression
- Bipolar disorder
- Schizophrenia
- Catatonia
- Agitation in dementia (off-label)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Brent Forester
Lead Sponsor
Mayo Clinic
Collaborator
Pine Rest Christian Mental Health Services
Collaborator
Emory University
Collaborator
The Zucker Hillside Hospital
Collaborator
Medical University of South Carolina
Collaborator