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ECT for Dementia (ECT-AD Trial)
ECT-AD Trial Summary
This trial will compare two treatments for severe agitation in patients with dementia: electroconvulsive therapy plus usual care (ECT+UC) versus placebo simulated electroconvulsive therapy plus usual care (S-ECT+UC). The study will also compare the safety and tolerability of the two treatments.
ECT-AD Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowECT-AD Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.ECT-AD Trial Design
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Who is running the clinical trial?
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- I have never had a stroke, confirmed by physical and neurological exams.I have been diagnosed with a form of dementia.I am 40 years old or older.I have been diagnosed with Dementia with Lewy Bodies.You have shown signs of aggression or potentially dangerous behavior during a previous assessment.I have been diagnosed with vascular dementia caused by a stroke.I am currently diagnosed with delirium alongside other conditions.You scored 15 or lower on the Mini Mental Status Exam (MMSE).My condition is diagnosed as vascular dementia.My health is stable enough for ECT, confirmed by tests and possibly brain scans.I have been diagnosed with Alzheimer's dementia.I have been diagnosed with frontotemporal dementia.My illness started slowly and has been getting worse over time.I have been diagnosed with a specific type of dementia.I haven't had ECT or similar therapies in the last 3 months.You have been diagnosed with schizophrenia, bipolar disorder, or schizoaffective disorder at any time in your life.You have struggled with drug or alcohol addiction in the past 6 months.I have tried at least one medication for behavioral symptoms that didn't work.
- Group 1: ECT+UC group
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Who fulfills the criteria to join this trial?
"This trial aims to enroll 200 individuals aged 55-89 suffering from akathisia. To qualify, a patient must have been diagnosed with one of the following dementias according to NIA-AA Criteria: Alzheimer's dementia, Frontotemporal dementia, or Dementia with Lewy Bodies; show an MMSE score ≤ 15 as well as evidence of microvascular ischemic disease and clinical decline on MRI scans; and demonstrate at least 5 points in Cohen-Mansfield Agitation Inventory Short Version aggression/dangerous items (1-11, 14, 15, 22-24) that may include physical"
How many participants are enrolling in the experiment?
"This medical experiment necessitates that 200 individuals, who meet the established admittance criteria, partake in this trial from sites such as Mayo Clinic located in Rochester, Minnesota and Pine Rest Christian Mental health Services based out of Grand Rapids, Michigan."
Is the inclusion criterion for this research study restricted to individuals above a certain age?
"The age range specified by the parameters of this trial is 55 to 89 years old."
Is this experimental procedure available to participants at the present moment?
"Affirmative. The information made accessible on clinicaltrials.gov indicates that this research project, which was initially advertised in January 2021 is currently recruiting subjects. About 200 people are needed from 5 distinct medical centres to complete the trial."
Are there any medical facilities in North America currently executing this experiment?
"Patients are being recruited to the trial in various regions, including Mayo Clinic Rochester, Pine Rest Christian Mental health Services Grand Rapids and McLean Hospital Belmont. Additionally, there are 5 other recruiting sites."
Who else is applying?
What state do they live in?
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What portion of applicants met pre-screening criteria?
How many prior treatments have patients received?
Why did patients apply to this trial?
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