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Intermittent Fasting Diet for Psoriasis and Psoriatic Arthritis

N/A

Recruiting

Led By Benjamin H Kaffenberger, MD, MS

Research Sponsored by Ohio State University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

18 years of age and older

Established patient at the clinical site with a diagnosis of mild to moderate plaque psoriasis despite treatment

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 0 weeks (baseline), 12 weeks, 24 weeks

Awards & highlights

Study Summary

This trial is studying whether intermittent fasting can improve psoriasis & PsA disease severity & quality of life. It will look at clinical parameters, biometric measurements, & quality of life indices. Results will help determine the role of IMF & other diets in psoriasis & provide dietary recommendations.

Who is the study for?

This trial is for adults over 18 with mild to moderate plaque psoriasis, who are overweight and have been stable on their current psoriasis treatment for at least 6 weeks. It's not suitable for insulin-dependent diabetics, pregnant or breastfeeding individuals, those with severe organ disease, or anyone using medical weight loss treatments.Check my eligibility

What is being tested?

The study tests if an Intermittent Fasting Diet (IMF) can improve the severity of psoriasis and Psoriatic Arthritis (PsA), as well as quality of life. Participants will either follow the IMF diet or their usual diet for 24 weeks. The effects will be monitored through regular check-ins and assessments by a physician.See study design

What are the potential side effects?

While intermittent fasting is generally considered safe, potential side effects may include hunger, fatigue, headaches, irritability during fasting periods. Long-term adherence could potentially affect metabolism.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am 18 years old or older.

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I have mild to moderate plaque psoriasis and treatments haven't worked.

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I haven't changed my psoriasis treatment in the last 6 weeks.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 0 weeks (baseline), 12 weeks, 24 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~0 weeks (baseline), 12 weeks, 24 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and 0 weeks (baseline), 12 weeks, 24 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Joints

Skin

Secondary outcome measures

Skin

Body Mass Index (BMI)

Nail plate

+6 more

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Intermittent Fasting GroupExperimental Treatment1 Intervention

Patients in this group will do intermittent fasting dieting for 12 weeks, meaning they will only eat for 8 hours per day. They may choose whichever 8 hours they want. Only water can be consumed during the fasting period. For the last 12 weeks of the study, they will resume their normal diet.

Group II: Standard Routine Diet GroupActive Control1 Intervention

Patients will continue with their normal diets for the 24 week duration of the study.

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

National Psoriasis FoundationOTHER

11 Previous Clinical Trials

1,822 Total Patients Enrolled

2 Trials studying Psoriatic Arthritis

542 Patients Enrolled for Psoriatic Arthritis

Ohio State UniversityLead Sponsor

829 Previous Clinical Trials

505,575 Total Patients Enrolled

Benjamin H Kaffenberger, MD, MSPrincipal InvestigatorThe Ohio State University Wexner Medical Center

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this research program actively seeking participants?

"Indeed, the information hosted on clinicaltrials.gov allude to this trial's active recruitment of 60 patients from a single site. This experiment was first posted on July 21st 2022 and its details were last amended on October 19th 2022."

Answered by AI

What are the projected results of this medical study?

"The primary goal of this trial, assessed at the 0-week baseline and then again at 12 weeks and 24 weeks, is to assess changes in disease activity (joints) using a PsARC scoring rubric. Secondary objectives involve evaluating enthesitis/dactylitis through physical examinations, measuring patient weight on traditional clinical scales, and assessing overall disease activity by Physician's Global Assessment score (0-4; 4 being most severe)."

Answered by AI

What is the approximate size of the cohort participating in this experiment?

"Affirmative. According to the records on clinicaltrials.gov, this medical experiment was initially advertised on July 21st 2022 and has been recently updated on October 19th of the same year. The researchers are looking for 60 participants that can take part in their research at a single site."

Answered by AI

Recent research and studies

ObesityJournal

Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting

Anton, Stephen D., Keelin Moehl, William T. Donahoo, Krisztina Marosi, Stephanie A. Lee, Arch G. Mainous III, Christiaan Leeuwenburgh, and Mark P. Mattson. 2017. “Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting”. Obesity. Wiley. doi:10.1002/oby.22065.

Ageing Research ReviewsJournal

Impact of Intermittent Fasting on Health and Disease Processes

Mattson, Mark P., Valter D. Longo, and Michelle Harvie. 2017. “Impact of Intermittent Fasting on Health and Disease Processes”. Ageing Research Reviews. Elsevier BV. doi:10.1016/j.arr.2016.10.005.

clinicaltrials.govStudy

Role of Intermittent Fasting in Psoriasis and Psoriatic Arthritis

Ben H Kaffenberger 2022. "Role of Intermittent Fasting in Psoriasis and Psoriatic Arthritis". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05590247.

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