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Radiation Therapy

CyberKnife SBRT for Prostate Cancer (CK-DESPOT Trial)

N/A
Recruiting
Research Sponsored by Crozer-Keystone Health System
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Unfavorable Risk Prostate Carcinoma as Described is documented.
No prior Trans-urethral resection of the prostate (TURP).
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 5 years
Awards & highlights

CK-DESPOT Trial Summary

This trial is testing whether CK-SBRT is an effective treatment for prostate cancer, especially in those with unfavorable types of the disease.

Who is the study for?
Men with a specific type of prostate cancer that hasn't spread, diagnosed within the last year. They should have a prostate size less than 100 cc, low urinary symptoms (AUA score <20), and no prior major prostate surgeries or pelvic radiation. Men who've had other cancers besides non-melanoma skin cancer in the past 5 years or those with implanted hardware near the prostate are not eligible.Check my eligibility
What is being tested?
The trial is testing CyberKnife SBRT, an advanced form of targeted radiation therapy designed to increase dosage accuracy for treating unfavorable types of localized prostate cancer while minimizing damage to surrounding healthy tissue.See study design
What are the potential side effects?
Potential side effects may include urinary issues, bowel discomfort, fatigue, sexual dysfunction, and skin reactions in the treated area. The precise nature and severity can vary based on individual patient factors.

CK-DESPOT Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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My prostate cancer is classified as high-risk.
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I have not had a TURP procedure.
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My prostate is smaller than 100 cubic centimeters.
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I have not had radiation therapy to my pelvic area.
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I haven't had any cancer besides non-melanoma skin cancer in the last 5 years.
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My prostate cancer was confirmed by a biopsy within the last year.
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My scans show no cancer spread to lymph nodes or distant parts of the body.
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I am eligible for a procedure to insert a rectal spacer.
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I don't have any implants near my prostate that would interfere with treatment.

CK-DESPOT Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Bladder and Rectal Toxicity using NCI common toxicity criteria version 4.0
Secondary outcome measures
Biochemical Disease Free Survival
Disease Free Survival
Disease Specific Survival
+3 more

CK-DESPOT Trial Design

1Treatment groups
Experimental Treatment
Group I: Dose Escalated CyberKnife SBRTExperimental Treatment1 Intervention

Find a Location

Who is running the clinical trial?

Crozer-Keystone Health SystemLead Sponsor
4 Previous Clinical Trials
194 Total Patients Enrolled

Media Library

CyberKnife SBRT (Radiation Therapy) Clinical Trial Eligibility Overview. Trial Name: NCT03822494 — N/A
Prostate Cancer Research Study Groups: Dose Escalated CyberKnife SBRT
Prostate Cancer Clinical Trial 2023: CyberKnife SBRT Highlights & Side Effects. Trial Name: NCT03822494 — N/A
CyberKnife SBRT (Radiation Therapy) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03822494 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this investigation still open to enrollees?

"Absolutely, the information on clinicaltrials.gov affirms that this research is actively searching for enrollees. It was initially announced on July 12th 2018 and last updated April 19th 2021; 100 participants are sought from a single medical facility."

Answered by AI

How many participants are currently being allowed to join this clinical research?

"Affirmative. Clinicaltrials.gov records indicate that this experiment is actively searching for participants, first posted on July 12th 2018 and recently updated April 19th 2021. The study requires 100 individuals from a single medical centre."

Answered by AI
~15 spots leftby Mar 2025