Sweeteners for Prediabetes
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Purdue University
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Trial Summary
What is the purpose of this trial?
This study will focus on changes in blood sugar in response to tasting different types of sweeteners using continuous glucose monitoring (CGM) technology.
Research Team
RM
Richard Mattes, PhD
Principal Investigator
Purdue University
Eligibility Criteria
This trial is for healthy adults aged 18 to 70 without diabetes, heart disease, metabolic disorders, or other chronic conditions affecting blood sugar. Participants should not have had major surgeries or be on medications that alter glucose metabolism or taste perception.Inclusion Criteria
No dietary restrictions or sensitivities that prevent them from tasting or swishing sweeteners and rice cakes provided during the study
I am in good health without diabetes, heart disease, or other chronic conditions affecting blood sugar.
I haven't had major surgeries or procedures that could affect my blood sugar levels.
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Timeline
Screening
Participants are screened for eligibility to participate in the trial
1 day
1 visit (in-person)
Treatment
Participants undergo taste testing with different sweeteners and continuous glucose monitoring
10 days
Home-based, self-administered
Follow-up
Participants are monitored for safety and effectiveness after treatment
2 weeks
Treatment Details
Interventions
- No Oral Stimulation
- Oral Salt Stimulation
- Oral Sucralose Stimulation
- Oral Sucrose Stimulation
- Oral Water Stimulation
Trial Overview The study tests how different sweeteners (sucralose and sucrose) and controls (salt, water, no stimulation) affect blood sugar levels using continuous glucose monitoring in people with prediabetes.
Participant Groups
5Treatment groups
Experimental Treatment
Group I: Oral Water StimulationExperimental Treatment1 Intervention
Oral stimulation with water.
Group II: Oral Sucrose stimulationExperimental Treatment2 Interventions
Oral stimulation with sucrose.
Group III: Oral Sucralose StimulationExperimental Treatment1 Intervention
Oral stimulation with sucralose.
Group IV: Oral Salt StimulationExperimental Treatment1 Intervention
Oral stimulation with salt.
Group V: No Oral StimulationExperimental Treatment1 Intervention
No oral stimulation is provided.
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Who Is Running the Clinical Trial?
Purdue University
Lead Sponsor
Trials
239
Recruited
72,200+
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