CyTOF Analysis for Pancreatitis
(MoSAIC Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to develop a tool to quickly predict severe cases of acute pancreatitis (a sudden inflammation of the pancreas) and to understand the immune response differences between severe and moderate cases. Participants will assist researchers by providing blood samples and sharing their experiences through surveys and interviews shortly after hospital admission. Individuals diagnosed with acute pancreatitis and hospitalized within 36 hours of symptom onset may be suitable for this study. As an unphased trial, this study allows participants to contribute to groundbreaking research that could enhance future diagnosis and treatment.
Do I need to stop my current medications to join the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the research team or your doctor.
Why are researchers excited about this trial?
Researchers are excited about this trial for acute pancreatitis because it explores the connection between immune signatures and clinical outcomes. Unlike current treatments, which mainly focus on managing symptoms and complications, this trial aims to uncover specific immune patterns that could predict patient responses and recovery trajectories. By identifying these unique immune signatures, the study could pave the way for more personalized and effective treatment strategies in the future, potentially transforming how acute pancreatitis is managed.
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Observation
Participants provide blood samples and complete patient surveys and interviews within 36 hours of hospital presentation, at 48 hours, and hospital day 7 if admitted
Data Collection and Analysis
Data on hospital stay, medical history, clinical course, and severity of disease will be collected. Blood samples will be analyzed for immune assays and stored for future research
Follow-up
Participants' electronic health records will be accessed for 5 years from the time of enrollment to monitor long-term outcomes
What Are the Treatments Tested in This Trial?
Interventions
- CyTOF Analysis
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Patients meeting Revised Atlanta Criteria for diagnosis of acute pancreatitis
Find a Clinic Near You
Who Is Running the Clinical Trial?
Ohio State University
Lead Sponsor
Benaroya Research Institute
Collaborator
University of Pittsburgh
Collaborator
University of Southern California
Collaborator
University of Illinois at Chicago
Collaborator
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