Cryoanalgesia for Postoperative Pain
(REDUCE Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial examines the effectiveness of cryoanalgesia, a method of freezing nerves to reduce pain, for managing post-surgery pain. It targets the intercostal nerves, which run between the ribs. Individuals who have undergone or are scheduled for this nerve-freezing treatment for post-surgery pain relief may be suitable candidates.
As a Phase 2 trial, the research measures the treatment's effectiveness in an initial, smaller group, allowing participants to contribute to important early-stage findings.
Do I have to stop taking my current medications for this trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that cryoanalgesia of the intercostal nerves is safe for post-operative pain management?
Research has shown that cryoanalgesia, which uses extreme cold to numb nerve fibers, is a promising method for pain relief. Studies indicate that it provides long-lasting relief by temporarily stopping the function of nerves between the ribs. This treatment eliminates the need for repeated nerve block injections, which can have side effects.
Evidence suggests that cryoanalgesia is well-tolerated and avoids the risks associated with some long-lasting pain medications. While it temporarily interrupts nerve function, it does not cause permanent damage. This reversibility makes it a safe option for managing pain, especially after surgery. So far, studies have not frequently reported any significant adverse effects.12345Why are researchers excited about this trial?
Cryoanalgesia of the intercostal nerves is unique because it targets pain directly by freezing the nerves responsible for transmitting pain signals. This method stands out from typical pain management approaches, such as medications or nerve blocks, which can have systemic side effects or provide only temporary relief. Researchers are excited because cryoanalgesia offers the potential for longer-lasting pain relief with minimal side effects, presenting a promising option for individuals seeking effective management of pain in the chest area.
What evidence suggests that cryoanalgesia of the intercostal nerves is effective for post-operative pain management?
Research has shown that freezing the nerves between the ribs, known as cryoanalgesia, can help manage post-surgical pain. One study found that patients experienced less pain and required fewer painkillers in the first 24 hours after surgery. Another study confirmed the safety and effectiveness of this method for pain relief following chest surgery. Some studies also noted reduced pain medication use when cryoanalgesia was part of the treatment. However, one study did not observe a decrease in pain or painkiller use and reported an increase in nerve-related pain a few weeks after treatment. Overall, while more research is needed, this treatment appears promising in certain situations.678910
Who Is on the Research Team?
Curits Quinn, MD
Principal Investigator
Elliot Hospital
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo cryoablation of the intercostal nerves for post-operative pain management
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Cryoanalgesia of the Intercostal Nerves
Find a Clinic Near You
Who Is Running the Clinical Trial?
AtriCure, Inc.
Lead Sponsor