Family History Screening for BRCA-Associated Cancers
(RSPH5973-23 Trial)
Trial Summary
What is the purpose of this trial?
This clinical trial adapts and evaluates the effectiveness of a family history screening program (GA CORE) for increasing uptake of genetic screening for BRCA-associated cancers in women who have received care in rural public health clinics in Southwest Georgia. Brief and low-cost family history-based screening assessments to identify families at high risk for BRCA-associated cancers have been endorsed by national guidelines and public health organizations. Georgia is among the few states to have implemented statewide family history screening for BRCA-associated cancers. Despite its potential, current clinic-based approaches that identify at-risk women are not sustainable and show limited reach. Additionally, uptake of follow-up cancer screening is sub-optimal and solely focuses on women screened as high genetic risk. This trial will adapt the existing family history screening program and then evaluate it's effectiveness for increasing the number and diversity of women who receive a history assessment and subsequent access to risk-based services such as genetic counseling and testing.
Research Team
Yue Guan
Principal Investigator
Emory University Hospital/Winship Cancer Institute
Eligibility Criteria
This trial is for women who have used rural public health clinics in Southwest Georgia and may be at high risk for BRCA-associated cancers like breast or ovarian cancer. It aims to improve genetic screening uptake by adapting a family history screening program.Inclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Adaptation and Preparation
Conduct a multilevel adaptation of GA CORE's existing statewide family history screening program for BRCA-associated cancers to maximize sustainable program reach and improve communication suitability and effectiveness.
Implementation
Evaluate the effectiveness of the adapted program relative to the current screening program in promoting uptake of family history screening and correct screening result interpretation among women ages 25 and older.
Follow-up
Participants are monitored for safety and effectiveness after treatment, including uptake of genetic consultation and testing, and mammogram screening behaviors.
Treatment Details
Interventions
- Adapted Family History Screening Program
Find a Clinic Near You
Who Is Running the Clinical Trial?
Emory University
Lead Sponsor
National Cancer Institute (NCI)
Collaborator