Pain Management Treatments for Knee Osteoarthritis
(iGOR Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to gather information on different treatments for managing chronic knee pain caused by osteoarthritis (OA) or to optimize pain relief after knee replacement surgery. The treatments under study include nerve blocks, radiofrequency ablation, corticosteroid injections, and various pain relievers. Individuals with knee OA planning to receive any of these treatments within the next 60 days might be suitable candidates. Participants must be comfortable using a smartphone or computer to complete questionnaires. As a Phase 2 trial, this research measures the effectiveness of these treatments in an initial, smaller group, allowing participants to contribute to advancements in pain management.
Do I need to stop my current medications for the trial?
The trial information does not specify if you need to stop your current medications. It might be best to discuss this with the trial coordinators or your doctor.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research has shown that several treatments for knee osteoarthritis (OA) pain are promising in terms of safety. For cryo nerve block and radiofrequency ablation (RFA), studies suggest these treatments are generally well-tolerated, with only minor side effects like temporary numbness or discomfort in some patients.
Intra-articular (IA) corticosteroids are also commonly used for knee OA. They are generally safe but may cause mild side effects such as swelling or a brief increase in pain at the injection site. A doctor should monitor long-term use.
Viscosupplementation, which involves injecting a gel-like fluid into the knee, is another option. It is considered safe, with most patients experiencing only mild, short-term swelling or pain at the injection site.
Opioids present more significant safety concerns due to the risk of addiction and side effects like dizziness or constipation. Doctors usually prescribe them at the lowest effective dose and for the shortest time possible to minimize risks.
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for pain relief. They are well-tolerated by most people but can cause stomach upset or, in rare cases, more serious issues like ulcers or kidney problems, especially with long-term use.
Overall, these treatments have been studied extensively and shown to be relatively safe. Patients should always discuss their specific situations with their doctors to weigh the benefits and risks.12345Why are researchers excited about this trial?
Researchers are excited about this trial because it aims to discover innovative ways to manage knee osteoarthritis (OA) pain. Unlike current treatments that often rely on medications like NSAIDs or corticosteroid injections to alleviate symptoms, this trial is exploring unique approaches to pain management directly targeting the knee. The focus is on understanding the outcomes of these novel methods, potentially leading to more effective and tailored pain relief options for patients with knee OA. This could revolutionize how we approach knee OA treatment and improve quality of life for many suffering from this condition.
What evidence suggests that this trial's treatments could be effective for knee OA pain?
Research has shown that several treatments can help manage knee osteoarthritis (OA) pain. In this trial, participants will receive a specific treatment for knee OA. Cryo nerve block and radiofrequency ablation (RFA) target and block pain signals from the affected nerves, providing relief. Injecting corticosteroids directly into the knee joint reduces inflammation and pain. Viscosupplementation, which involves injecting a lubricating fluid into the knee, improves movement and reduces pain. Exercise therapies, such as strengthening and flexibility exercises, have effectively improved pain, function, and quality of life. Additionally, combining hyaluronic acid with platelet-rich plasma has shown promise in reducing stiffness and improving physical function.12678
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive various pain management therapies for knee osteoarthritis, including cryo nerve block, radiofrequency ablation, intra-articular corticosteroids, and others
Follow-up
Participants are monitored for safety and effectiveness after treatment, including assessments of opioid use, functional status, pain intensity, and patient satisfaction
What Are the Treatments Tested in This Trial?
Interventions
- Treatment for Knee OA
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Eligible and enrolled subjects with knee OA pain who require treatment on the target knee as a part of pain management.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Pacira Pharmaceuticals, Inc
Lead Sponsor
Dr. Jonathan Slonin
Pacira Pharmaceuticals, Inc
Chief Medical Officer since 2020
BSc in Biomedical Engineering and MD from University of Miami, MBA from George Washington University
Frank D. Lee
Pacira Pharmaceuticals, Inc
Chief Executive Officer since 2024
BSc in Chemical Engineering from Vanderbilt University, MBA from Wharton Graduate School of Business
Citations
Effectiveness of Rehabilitation for Osteoarthritis of the Knee
Our results suggested that exercise therapies, including muscle-strengthening, aerobic, flexibility, and mind-body exercises, are likely to be effective for ...
A network meta-analysis based on randomized clinical trials
The findings suggest that knee brace may be the most recommended therapeutic option for the knee osteoarthritis, followed by hydrotherapy and exercise.
systematic review and network meta-analysis
The findings demonstrated that exercise was effective at improving pain, function, gait performance, and quality of life in individuals with ...
Recent advances in the management of knee osteoarthritis
This review overviews current therapeutic options for knee OA pain, focusing on their efficacy, safety, and potential roles in clinical practice.
Comparative efficacy of treatments for patients with knee ...
Hyaluronic acid combined with platelet-rich plasma showed the best efficacy in improving stiffness, physical function, and total scores.
6.
aaos.org
aaos.org/globalassets/quality-and-practice-resources/osteoarthritis-of-the-knee/oak3cpg.pdfManagement of Osteoarthritis of the Knee (Non-Arthroplasty)
Three prospective randomized controlled trials compared bracing to control groups for treatment of symptomatic OA of the knee joint and found ...
7.
bmcmusculoskeletdisord.biomedcentral.com
bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/s12891-019-2525-0Osteoarthritis- a systematic review of long-term safety ...
This systematic review aims to appraise the current evidence for the long-term (≥12 months) safety of common treatments for knee osteoarthritis (KOA).
Genicular artery embolization for treatment of knee ...
Limited evidence suggests that GAE is a safe procedure that confers improvement in knee OA symptoms at established MCID thresholds.
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