fMRI Brain Scan for Chronic Knee Pain
(fMRI-TKA Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
Knee replacement surgery is a common and effective treatment for pain and mobility loss, yet up to 1 in 5 patients remain dissatisfied after surgery due to ongoing pain or difficulty with daily activities. Currently, clinicians cannot reliably predict which patients will experience these challenges.
This study uses MRI scan of the brain to investigate whether specific patterns of brain activity can predict patient satisfaction after total knee arthroplasty (TKA). By comparing brain networks before surgery and afterward, and linking these changes to patient-reported pain and function, we aim to identify brain-based markers that can help predict outcomes, to improve satisfaction after knee replacement surgery.
Who Is on the Research Team?
Simon Garceau
Principal Investigator
The Ottawa Hospital
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Preoperative Assessment
Preoperative resting-state fMRI brain connectivity is assessed as a predictor of postoperative patient satisfaction
Surgery and Immediate Postoperative Period
Participants undergo total knee arthroplasty and initial recovery
Follow-up
Longitudinal changes in brain network connectivity are assessed from preoperative to 12 months postoperative
What Are the Treatments Tested in This Trial?
Interventions
- fMRI Brain Scan
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Find a Clinic Near You
Who Is Running the Clinical Trial?
Ottawa Hospital Research Institute
Lead Sponsor
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