Study Summary
This trial aims to test the effect of tVNS on knee OA pain and autonomic function, measuring pain severity, central pain sensitivity, and heart rate variability.
- Osteoarthritis of the Knee
- Central Pain Syndrome
Treatment Effectiveness
Phase-Based Effectiveness
Study Objectives
8 Primary · 5 Secondary · Reporting Duration: Immediately before tVNS intervention
Trial Safety
Phase-Based Safety
Awards & Highlights
Trial Design
1 Treatment Group
tVNS group
1 of 1
Experimental Treatment
30 Total Participants · 1 Treatment Group
Primary Treatment: tVNS group · No Placebo Group · N/A
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 45 - 90 · All Participants · 5 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:Frequently Asked Questions
Does this clinical study include elderly participants aged 70 and over?
"Patients aged between 45 and 90 are eligible to apply for this trial. Additionally, there are 37 medical studies available specifically for minors and a further 670 clinical trials accessible by individuals over the age of 65." - Anonymous Online Contributor
Are enrollees being accepted at this point in the clinical trial?
"Based on the information posted to clinicaltrials.gov, this trial is still recruiting patients at the time of writing. It was first listed on December 15th 2022 and its details were last modified on May 9th 2023." - Anonymous Online Contributor
Am I eligible to partake in this clinical experiment?
"For this clinical trial, 30 individuals aged 45 to 90 with osteoarthritis are being sought. All applicants must demonstrate chronic [knee pain](https://www.withpower.com/clinical-trials/knee-pain) consistent with such a diagnosis (no imaging required), at least 3 months of discomfort that rates 4/10 or higher on the pain scale, and have no morning stiffness for over half an hour. Moreover, all participants need to understand English as it is the official language of communication." - Anonymous Online Contributor
Are there limits to the number of participants accepted into this medical experiment?
"Affirmative. Clinicaltrials.gov data demonstrate that this medical research study, which was initially posted on December 15th 2022 and most recently modified on May 9th 2023, is currently enrolling 30 patients from a single site." - Anonymous Online Contributor
What core aims is this medical trial hoping to achieve?
"The primary goal of this clinical trial, assessed over the course of one day via three data points (baseline, immediate post-intervention, and 15 minutes after tVNS intervention) is to measure Patient Satisfaction. Secondary objectives include quantifying Ethnic Identity using a 12 item survey with 1-4 point scale (1 meaning poor identity, 4 strong), Fear Avoidance Beliefs measured by 16 questions graded from 0 to 6 (where higher numbers equate to heightened fear responses), and Sleep Quality analyzed through a 19 question questionnaire producing an overall score ranging between 0 and 21 (0-4 indicating absence of sleep issues)." - Anonymous Online Contributor