70 Participants Needed

Endurance Exercise for Obesity

(ATLAS Trial)

Recruiting at 1 trial location
RD
Overseen ByRecruitment Department
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Approved in 1 JurisdictionThis treatment is already approved in other countries

Trial Summary

Will I have to stop taking my current medications?

The trial does not specify if you must stop taking your current medications, but certain medications are exclusionary, such as those for cardiovascular, psychiatric, pulmonary, hormonal, and other conditions. If you are on any of these medications, you may not be eligible to participate.

What data supports the effectiveness of the treatment Endurance Exercise, Aerobic Exercise, Cardiovascular Exercise for obesity?

Research shows that aerobic exercise can improve quality of life and physical performance in people with obesity. It also helps with weight loss, reduces body fat, and improves heart health, even if the weight loss is modest.12345

Is endurance exercise safe for people with obesity?

Endurance exercise, also known as aerobic or cardiovascular exercise, is generally considered safe for people with obesity. Studies show it can improve metabolic health, such as lowering blood sugar levels, without significant safety concerns.678910

How does endurance exercise as a treatment for obesity differ from other treatments?

Endurance exercise, like aerobic or cardiovascular exercise, is unique because it not only helps with weight loss but also improves heart and muscle health, increases metabolism, and enhances glucose regulation. Unlike some treatments that focus solely on diet or medication, endurance exercise offers a holistic approach by improving overall fitness and reducing risks associated with obesity-related conditions.5681112

What is the purpose of this trial?

The purpose of this research study is to study the effects of endurance exercise training on adipose (fat) tissue quality and insulin sensitivity in men and women.

Research Team

LS

Lauren Sparks, PhD

Principal Investigator

AdventHealth Translational Research Institute

UW

Ursula White, PhD

Principal Investigator

Pennington Biomedical Research Center

Eligibility Criteria

This trial is for men and pre-menopausal women aged 18-45 with obesity (BMI of 30.0-40.0), leading a sedentary lifestyle, who haven't had significant weight or lifestyle changes recently. Participants must understand English, agree to use birth control if applicable, and commit to the study's procedures.

Inclusion Criteria

BMI 30.0-40.0 kg/m2
For women not using pharmaceutical contraception, must agree to use specified birth control methods
Sedentary lifestyle defined as minimal exercise in the past year
See 4 more

Exclusion Criteria

Unstable body weight in the last 3 months
Significant changes in diet or physical activity in the last 3 months
Weight >396 lb (180 kg)
See 5 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo endurance exercise training or control (no exercise) for 12 weeks

12 weeks

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

Treatment Details

Interventions

  • Endurance Exercise
Trial Overview The study investigates how endurance exercise affects fat tissue quality and insulin sensitivity in obese individuals. It involves muscle and fat biopsies, heavy water labeling, glucose clamp tests, monitoring physical activity/dietary habits using an accelerometer.
Participant Groups
2Treatment groups
Active Control
Group I: Control (CTRL) groupActive Control6 Interventions
Group II: Endurance exercise (EX) groupActive Control6 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

AdventHealth Translational Research Institute

Lead Sponsor

Trials
51
Recruited
5,900+

Pennington Biomedical Research Center

Collaborator

Trials
314
Recruited
183,000+

Findings from Research

In a study involving 73 patients with severe obesity, both moderate-intensity continuous training (MICT) and a combined high-intensity interval training with MICT (HIIT/MICT) program led to significant improvements in health-related quality of life (HRQOL) after 24 weeks, with no significant difference between the two exercise intensities.
Both exercise programs resulted in moderate improvements in various quality of life measures, indicating that the benefits of exercise on health may not depend on the intensity of the workout.
Effect of aerobic exercise intensity on health-related quality of life in severe obesity: a randomized controlled trial.Berge, J., Hjelmesæth, J., Kolotkin, RL., et al.[2022]
Exercise has numerous benefits for individuals with obesity, including aiding in weight loss and improving cardiovascular health, but the direct impact on weight loss from exercise alone is modest, typically resulting in only a few kilograms of weight loss.
Physical activity is crucial for managing type 2 diabetes and preventing its complications, and a structured approach like the 5 A's strategy can help healthcare professionals effectively support patients in overcoming barriers to increasing their physical activity levels.
Physical activity in management of persons with obesity.Oppert, JM., Bellicha, A., Ciangura, C.[2021]
A structured, home-based exercise program significantly improved physical performance and quality of life in patients with obesity, as demonstrated by a cohort of 151 participants over a 3-month period.
After the program, participants showed notable enhancements in walking distance, speed, and VO2max, indicating that even simple exercise routines can have substantial health benefits for individuals with obesity.
Usefulness of an Easy, Structured, and Home-Based Exercise Program to Improve Physical Performance and Quality of Life in a Patient's Cohort with Obesity.López-López, CO., Montes Castillo, ML., Aguilar-Serralde, CA., et al.[2023]

References

Effect of aerobic exercise intensity on health-related quality of life in severe obesity: a randomized controlled trial. [2022]
Physical activity in management of persons with obesity. [2021]
Usefulness of an Easy, Structured, and Home-Based Exercise Program to Improve Physical Performance and Quality of Life in a Patient's Cohort with Obesity. [2023]
Physical activity, diet and behaviour modification in the treatment of overweight and obese adults: a systematic review. [2018]
More exercise for the obese? [2006]
Muscle FOXO-Specific Overexpression and Endurance Exercise Protect Skeletal Muscle and Heart from Defects Caused by a High-Fat Diet in Young Drosophila. [2023]
Physical exercise and morbid obesity: a systematic review. [2019]
Eight sessions of endurance training decrease fasting glucose and improve glucose tolerance in middle-aged overweight males. [2021]
Evaluation of exercise prescription for hypertensive obese men by ventilatory threshold. [2019]
Influences of Resistance versus Aerobic Exercise on Physiological and Physical Fitness Changes in Previously Inactive Men with Obesity: A Prospective, Single-Blinded Randomized Controlled Trial. [2022]
11.United Statespubmed.ncbi.nlm.nih.gov
Special ergometric techniques and weight reduction. [2013]
12.United Statespubmed.ncbi.nlm.nih.gov
Exercise physiology and cardiovascular fitness. [2008]
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