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Weight Loss Maintenance for Obesity (POWERS Trial)

N/A
Recruiting
Led By Susan Roberts, PhD
Research Sponsored by University of Pittsburgh
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up end of weight stabilization following at least 7 percent weight loss vs. 52 weeks after weight stabilization following at least 7 percent weight loss
Awards & highlights

POWERS Trial Summary

This trial will study how weight loss affects obese adults, with the goal of understanding how to maintain weight loss long-term.

Who is the study for?
Adults aged 25-59 with obesity (BMI: 30-<40 kg/m2) who've been stable in weight for the past 6 months, not pregnant or planning pregnancy within two years, without severe heart conditions, thyroid disease requiring medication, renal disease needing dialysis, liver issues, substance abuse problems, extreme dietary restrictions like veganism or very low carb/fat diets. Participants must have internet access and be able to do ergometry testing.Check my eligibility
What is being tested?
The study aims to understand why overweight individuals tend to regain weight after a behavioral weight loss program. It involves an initial evaluation followed by up to a 20-week program aiming for at least a 7% weight reduction from baseline within 37 weeks. Successful participants will then be monitored over one year with clinical exams at four and twelve months post-program.See study design
What are the potential side effects?
This trial does not involve medications; hence there are no direct side effects from interventions like drugs. However, participants may experience general stress related to lifestyle changes required during the behavioral weight loss program.

POWERS Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~end of weight stabilization following at least 7 percent weight loss vs. 52 weeks after weight stabilization following at least 7 percent weight loss
This trial's timeline: 3 weeks for screening, Varies for treatment, and end of weight stabilization following at least 7 percent weight loss vs. 52 weeks after weight stabilization following at least 7 percent weight loss for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Weight change from end of weight stabilization following at least 7 percent weight loss to 52 weeks after weight stabilization following at least 7 percent weight loss

Side effects data

From 2016 Phase 3 trial • 150 Patients • NCT00856609
98%
hunger decrease
60%
Nausea
57%
Headache
40%
Diarrhea
35%
Constipation
33%
Injection site reaction
33%
Gastroesophageal reflux
30%
Itchiness
28%
Vomiting
25%
hypoglycemia
15%
Skin rash
10%
Palpitations
100%
80%
60%
40%
20%
0%
Study treatment Arm
Placebo
Exenatide

POWERS Trial Design

1Treatment groups
Experimental Treatment
Group I: Weight lossExperimental Treatment1 Intervention
A 37 week behavioral intervention aimed at decreasing energy intake and increasing physical activity.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Weight loss
2010
Completed Phase 4
~1790

Find a Location

Who is running the clinical trial?

Drexel UniversityOTHER
150 Previous Clinical Trials
47,496 Total Patients Enrolled
30 Trials studying Obesity
6,412 Patients Enrolled for Obesity
Dartmouth CollegeOTHER
81 Previous Clinical Trials
1,415,485 Total Patients Enrolled
1 Trials studying Obesity
55 Patients Enrolled for Obesity
New York State Psychiatric InstituteOTHER
475 Previous Clinical Trials
153,702 Total Patients Enrolled
4 Trials studying Obesity
201 Patients Enrolled for Obesity

Media Library

Weight loss Clinical Trial Eligibility Overview. Trial Name: NCT05748158 — N/A
Obesity Research Study Groups: Weight loss

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this clinical experiment accept individuals aged 55 and over?

"The minimum age of entry for this investigation is 25, whereas the maximum age to qualify as a participant is 59."

Answered by AI

Are any individuals still being admitted into this medical experiment?

"Evidently, this specific medical trial is no longer accepting patients, as was last updated on April 7th 2023. According to clinicaltrials.gov data, it initially posted on June 1st 2023 and stopped recruiting at some point after that date. Fortunately there are still 977 other trials actively seeking participants currently."

Answered by AI

Am I eligible to join this research endeavor?

"This clinical research is looking to include 205 adults with obesity, aged 25-59 years old. The major requirements for selection are a BMI of 30 - <40 kg/m2 and the ability to complete ergometry testing."

Answered by AI

Who else is applying?

What site did they apply to?
University of Pennsylvania
What portion of applicants met pre-screening criteria?
Met criteria
Recent research and studies
clinicaltrials.govStudy
A Study to Investigate Why Overweight People Regain Weight After Losing Weight in a Behavioral Weight Loss Program
Steven Belle 2023. "A Study to Investigate Why Overweight People Regain Weight After Losing Weight in a Behavioral Weight Loss Program". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05748158.
~137 spots leftby Dec 2026
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