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Imaging Techniques for Angina

N/A

Waitlist Available

Led By Krishna Patel, MBBS, MSc

Research Sponsored by Icahn School of Medicine at Mount Sinai

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Patients with symptoms of exertional angina and/or dyspnea (confirmed on Seattle Angina Questionnaire and Rose Dyspnea Questionnaire)

Evidence of non-obstructive CAD on CCTA or coronary angiography (no stenosis >50% and/or FFR if performed >0.80)

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 3 months

Awards & highlights

Study Summary

This trial looks to develop a non-invasive algorithm to diagnose & manage patients with suspected angina & ischemia but no obstructive coronary artery disease (CAD). It will assess the improvement in patient symptoms, function & quality of life from PET-guided management.

Who is the study for?

This trial is for patients with symptoms of exertional angina or shortness of breath, who have non-obstructive coronary artery disease confirmed by tests. It's not for those with severe kidney issues, certain heart conditions, pregnant women, or people unable to consent.Check my eligibility

What is being tested?

The study aims to develop a non-invasive method using PET scans and other imaging techniques to diagnose and manage microvascular dysfunction in patients without significant coronary artery blockages.See study design

What are the potential side effects?

Potential side effects may include reactions related to the PET imaging agent (like nausea), discomfort from exercise during the stress test, and risks associated with CT angiograms such as radiation exposure.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I experience chest pain or shortness of breath when I exert myself.

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My heart's arteries are not severely blocked.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 3 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~3 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Euro-QOL 5 Dimension Visual Analog Scale (EQ5D-VAS)

Number of ER admissions for chest pain per participant

Number of use of other invasive or non-invasive diagnostic procedures for CAD

+2 more

Secondary outcome measures

Number of participants with METs >=10 METS

The Bruce protocol score

Trial Design

1Treatment groups

Experimental Treatment

Group I: Patients with INOCAExperimental Treatment4 Interventions

Patients to undergo coronary angiogram and/or coronary CT angiogram for suspected ischemic symptoms of angina and dyspnea but do not have obstructive epicardial coronary artery disease.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

PET imaging

2005

Completed Phase 3

~670

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

Icahn School of Medicine at Mount SinaiLead Sponsor

861 Previous Clinical Trials

525,206 Total Patients Enrolled

Krishna Patel, MBBS, MScPrincipal InvestigatorIcahn School of Medicine at Mount Sinai

Media Library

Patients with INOCA Clinical Trial Eligibility Overview. Trial Name: NCT05634031 — N/A

Angina Research Study Groups: Patients with INOCA

Angina Clinical Trial 2023: Patients with INOCA Highlights & Side Effects. Trial Name: NCT05634031 — N/A

Patients with INOCA 2023 Treatment Timeline for Medical Study. Trial Name: NCT05634031 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this research endeavor have any vacancies for new participants?

"As per the latest update on clinicaltrials.gov, this medical trial is no longer accepting participants; it was first published on December 1st 2022 and has not been updated since November 21st of the same year. Fortunately, there are 574 other studies that remain open for recruitment at present time."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Imaging Coronary Microvascular Dysfunction (CMD) Study

Krishna Patel 2023. "Imaging Coronary Microvascular Dysfunction (CMD) Study". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05634031.