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Home Exercise for Neurodegenerative Disease

N/A

Recruiting

Led By Jennifer Keller, PT

Research Sponsored by Hugo W. Moser Research Institute at Kennedy Krieger, Inc.

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

For females: X-linked adrenoleukodystrophy as determined by biochemical determination, genetic testing, or pedigree analysis

Leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation inclusion criterion: confirmed DARS2 mutation through genetic analysis

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline 12 weeks

Awards & highlights

Study Summary

This trialaims to develop treatments that improve walking ability in people with neurodegenerative diseases.

Who is the study for?

This trial is for individuals with specific neurodegenerative diseases like ataxia, leukodystrophy, or those with cerebellar damage due to stroke or tumor. Participants must have a confirmed genetic mutation related to their condition, be able to stand and walk with or without support, and not have other health issues that could interfere with the exercise program.Check my eligibility

What is being tested?

The study tests a home exercise regimen designed to improve walking abilities in people suffering from neurodegenerative diseases. It aims to create targeted therapeutic interventions tailored for these conditions.See study design

What are the potential side effects?

Since this trial involves home exercises, side effects may include muscle soreness, fatigue, and an increased risk of falls if exercises are not performed safely.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am a female diagnosed with X-linked adrenoleukodystrophy.

Select...

I have a confirmed DARS2 mutation linked to my leukoencephalopathy.

Select...

I am a male diagnosed with X-linked adrenoleukodystrophy.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline 12 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline 12 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline 12 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in NeuroQOL lower extremity

Trial Design

1Treatment groups

Experimental Treatment

Group I: Home exerciseExperimental Treatment1 Intervention

Individually designed home exercise program

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Home exercise

2017

Completed Phase 2

~1730

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

Hugo W. Moser Research Institute at Kennedy Krieger, Inc.Lead Sponsor

88 Previous Clinical Trials

24,906 Total Patients Enrolled

Jennifer Keller, PTPrincipal InvestigatorHugo W. Moser Research Institute at Kennedy Krieger, Inc.

Media Library

Home exercise Clinical Trial Eligibility Overview. Trial Name: NCT05443906 — N/A

Neurodegenerative Disease Research Study Groups: Home exercise

Neurodegenerative Disease Clinical Trial 2023: Home exercise Highlights & Side Effects. Trial Name: NCT05443906 — N/A

Home exercise 2023 Treatment Timeline for Medical Study. Trial Name: NCT05443906 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is there an opportunity to participate in this experiment?

"This investigation seeks 30 individuals between the ages of 5 and 75 who suffer from a range of neurological maladies. To be considered, male candidates must verify X-linked adrenoleukodystrophy through chemical assessment or genetic testing; females require biochemical analysis, hereditary examination, or pedigree evaluation to meet this criterion. Additionally, those with Leukoenceophalopathy with brainstem and spinal cord involvement coupled with an elevated lactate count ought to have their mutation identified via genetic scrutiny. Furthermore, people suffering from cerebellar ataxia--either caused by stroke damage, tumor growths (neoplasms), or degeneration--need provide"

Answered by AI

Are new participants being taken into this research endeavor at this time?

"Clinicaltrials.gov states that this medical research initiative, which was initially published on November 7th 2022 and subsequently edited the same day, is presently searching for participants."

Answered by AI

Are individuals over the age of 80 being included in this medical experiment?

"In compliance with the stipulations of this study, individuals must be between 5 and 75 years old to take part."

Answered by AI

What is the scope of involvement for participants in this clinical experiment?

"Affirmative. According to the clinicaltrial.gov, this study is actively seeking eligible participants; it was first posted on November 7th 2022 and has been recently updated as of same date. 30 individuals need to be enrolled at one medical centre."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Home Exercise for Individuals With Neurodegenerative Disease

jennifer keller 2023. "Home Exercise for Individuals With Neurodegenerative Disease". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05443906.

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