50000 Participants Needed

SRS/SBRT for Cancer

Recruiting at 30 trial locations
JJ
JD
Overseen ByJoanne Davis, PHD
Age: Any Age
Sex: Any
Trial Phase: Academic
Sponsor: The Radiosurgery Society
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial focuses on the use and effectiveness of SRS/SBRT, precise radiation therapies for treating life-threatening tumors and other conditions. Researchers collect data to evaluate the long-term effectiveness of these treatments and to determine optimal usage. It suits individuals diagnosed with benign (non-cancerous) or malignant (cancerous) tumors or conditions deemed treatable with these therapies by a doctor. Participants must agree to join and provide their consent. As a Phase 3 trial, this treatment represents the final step before FDA approval, offering participants an opportunity to contribute to groundbreaking research.

Do I need to stop my current medications for the trial?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What prior data suggests that SRS/SBRT is safe for treating life-threatening tumors and other diseases?

Research has shown that SRS (Stereotactic Radiosurgery) and SBRT (Stereotactic Body Radiation Therapy) are generally safe and well-tolerated. These methods have been used for many years and are known for their safety and effectiveness.

One study found that serious side effects occurred in about 9.4% of patients over three years. The most common serious side effect was pneumonitis, an inflammation of the lungs, which occurred in a small number of cases.

Overall, these treatments are considered safe for most patients, especially when used for specific conditions like tumors. The long history of using SRS and SBRT supports their safety record.12345

Why are researchers excited about this trial?

Researchers are excited about SRS (Stereotactic Radiosurgery) and SBRT (Stereotactic Body Radiotherapy) because these treatments offer a precise and non-invasive alternative to traditional options like surgery or standard radiation therapy. Unlike conventional radiation, which can affect surrounding healthy tissues, SRS/SBRT delivers high doses of radiation with pinpoint accuracy, minimizing damage to nearby areas. This means fewer side effects and potentially quicker recovery times for patients. Plus, these treatments can be completed in fewer sessions, making the process more convenient and less burdensome for patients.

What evidence suggests that SRS/SBRT is effective for treating life-threatening tumors and other diseases?

Research has shown that SRS (Stereotactic Radiosurgery) and SBRT (Stereotactic Body Radiation Therapy), studied in this trial, can effectively treat various tumor types. These methods often match or surpass traditional radiation treatments. For instance, SBRT has successfully treated some prostate cancers, achieving survival rates similar to standard treatments. Patients with early-stage lung cancer treated with SBRT have also demonstrated promising long-term results. Overall, these treatments are effective and cost-efficient, offering a strong option for patients with serious tumors.678910

Who Is on the Research Team?

AM

Anand Mahadevan, MD

Principal Investigator

The Radiosurgery Society

Are You a Good Fit for This Trial?

Inclusion Criteria

Diagnosis of benign or malignant tumors or other conditions deemed treatable by stereotactic radiosurgery or stereotactic body radiotherapy
Willingness to sign an Informed Consent Document or verbally agree to participation

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Patients receive SRS/SBRT treatment for their condition

Immediate

Follow-up

Participants are monitored for survival, recurrence, and treatment toxicity

Up to 5 years

What Are the Treatments Tested in This Trial?

Interventions

  • SRS/SBRT
How Is the Trial Designed?
1Treatment groups
Experimental Treatment
Group I: Patients being treated by SRS/SBRTExperimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

The Radiosurgery Society

Lead Sponsor

Trials
1
Recruited
50,000+

VisionTree

Collaborator

Trials
1
Recruited
50,000+

Citations

Stereotactic Radiosurgery and Stereotactic Body Radiation ...Treatment outcomes for SRS and SBRT are usually superior or comparable, and cost-effective, relative to alternative techniques. Conclusion: Based on the review ...
The effectiveness and safety of stereotactic body ...The results show minor, non-significant differences in survival rates compared to conventional fractionation, a type of external radiation, after two and five ...
SBRT Proves Effective for Some Prostate Cancers - NCIOver the 5 years of follow-up, a total of 27% of men in the SBRT group and 18% in the standard radiation therapy group reported urinary problems ...
A prospective outcomes and cost-effective analysis of surgery ...To evaluate long-term outcomes, treatment costs, and quality of life associated with curative treatment of newly diagnosed stage I non-small ...
Clinical outcomes and efficacy of stereotactic body radiation ...The objective of this study is to report disease outcomes and toxicity with the use of stereotactic body radiation therapy (SBRT) in the treatment of pediatric ...
Quality and safety in stereotactic radiosurgery and stereotactic ...By most accounts, stereotactic radiosurgery and stereotactic body radiation therapy are safe and effective. SRS has been used for decades in the treatment of ...
Safety and Efficacy of Stereotactic Body Radiation Therapy ...The incidence of severe toxicity was 9.4% at 3 years. The most common severe toxicity was pneumonitis (n = 4). There was 1 possible treatment- ...
LCD - Stereotactic Radiation Therapy ...Use this page to view details for the Local Coverage Determination for Stereotactic Radiation Therapy: Stereotactic Radiosurgery (SRS) and Stereotactic Body ...
Evaluation of Safety of Stereotactic Body Radiotherapy for ...Standard ablative radiation schedules appear to be safe for patients with oligometastatic disease with 3 to 4 metastases or 2 metastases in close proximity to ...
Definition and requirements for stereotactic radiotherapyQuality and Safety Considerations in Stereotactic Radiosurgery and Stereotactic Body Radiation Therapy: An ASTRO Safety White Paper Update. Pract Radiat ...
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