Somatic Mosaicism for Brain Tumor
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores why children with central nervous system (CNS) tumors, such as brain tumors, might develop these conditions differently, even if they are twins. By collecting blood and saliva samples and administering questionnaires, researchers aim to uncover genetic clues that could explain these differences. The study specifically seeks twins where at least one has a CNS tumor. Families of twins who meet these criteria, including those where the affected twin has passed away but has a banked blood sample, may be eligible to join. As an unphased study, this trial offers families a unique opportunity to contribute to groundbreaking research that could lead to better understanding and treatments for CNS tumors.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Why are researchers excited about this trial?
Researchers are excited about this trial because it explores the genetic factors influencing brain tumors by analyzing biospecimens like blood and saliva from twins with central nervous system (CNS) tumors. Traditional treatments for CNS tumors usually focus on surgery, radiation, and chemotherapy, aiming to directly reduce or remove the tumor. However, this study is unique as it's not about a new drug or treatment but about gathering insights into how genetic differences impact tumor development. By understanding somatic mosaicism, or the genetic variations within the same person, scientists hope to uncover new pathways for future therapies, potentially leading to more personalized and effective treatments for brain tumors.
Who Is on the Research Team?
Jenny Poynter, PhD
Principal Investigator
University of Minnesota
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Sample Collection
Twins with CNS tumors will undergo blood and saliva DNA sample collection
Analysis
Sequence blood and saliva DNA samples from 25 MZ twin pairs using a panel of 94 known cancer-associated genes
Follow-up
Participants are monitored for safety and effectiveness after sample collection and analysis
What Are the Treatments Tested in This Trial?
Interventions
- Biospecimen collection
- Questionnaire Administration
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Twins with CNS tumors, identified through the Children's Oncology Group's Project:EveryChild (PEC) registry, will have both blood and saliva samples collected at the time of study enrollment.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Children's Oncology Group
Lead Sponsor
National Cancer Institute (NCI)
Collaborator
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