Radiotherapy Registry for Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to collect medical samples from individuals with cancer or non-cancerous tumors undergoing radiotherapy, a treatment using high-energy rays. Researchers seek to gather blood, urine, and tumor samples to understand how these conditions respond to treatment. They are testing two treatments: photodynamic therapy, a light-based treatment, and radiotherapy. Individuals diagnosed with a tumor and receiving radiotherapy might be suitable candidates, especially if they can consent to participate. As a Phase 2 trial, this research measures the treatment's effectiveness in an initial, smaller group, offering participants a chance to contribute to important findings.
Do I have to stop taking my current medications for this trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research has shown that photodynamic therapy (PDT) is generally safe, though it can cause some side effects. Commonly, people experience skin reactions such as pain, swelling, and redness. Mild sensitivity to light occurs in about 2.2% of patients.
Radiotherapy, another cancer treatment, also causes side effects. These may include fatigue, skin changes, and hair loss, but most resolve a few months after treatment ends. Each treatment carries risks, but they are usually manageable and temporary.12345Why are researchers excited about this trial?
Researchers are excited about the Radiation Oncology Registry and Biosample Repository trial because it aims to gather comprehensive data and biological samples that could significantly enhance our understanding of how treatments like Photodynamic Therapy (PDT) and Radiotherapy work in cancer care. Unlike standard treatments that primarily focus on immediate clinical outcomes, this trial seeks to uncover valuable insights into patient responses and treatment effectiveness over time. By analyzing this rich repository of information, researchers hope to develop more personalized and effective cancer treatment strategies, potentially leading to breakthroughs in how we combat various types of cancer.
What evidence suggests that photodynamic therapy and radiotherapy could be effective for cancer and benign tumors?
This trial will compare photodynamic therapy (PDT) and radiotherapy. Research has shown that PDT effectively treats certain skin cancers, such as basal cell carcinoma (BCC). In some studies, over 90% of patients experienced a complete response to PDT. However, this treatment may lead to a higher recurrence rate compared to surgery, though it often results in better cosmetic outcomes. Radiotherapy is a well-established treatment for various cancers, helping to destroy cancer cells and shrink tumors. It is used in about half of all cancer patients. Both PDT and radiotherapy have shown promise, but their effectiveness can depend on the cancer's type and stage.678910
Who Is on the Research Team?
Jay Dorsey, MD, PhD
Principal Investigator
University of Pennsylvania
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Radiotherapy
Participants undergo radiotherapy while contributing to the registry and biosample repository
Follow-up
Participants are monitored for safety and effectiveness after radiotherapy
What Are the Treatments Tested in This Trial?
Interventions
- Photodynamic Therapy
- Radiotherapy
Find a Clinic Near You
Who Is Running the Clinical Trial?
Abramson Cancer Center of the University of Pennsylvania
Lead Sponsor
Abramson Cancer Center at Penn Medicine
Lead Sponsor
Citations
Global Trends and Research Progress of Photodynamic ...
The clinical trial of 25 patients with kidney transplantation showed that AK occurred in 63% of the patients, but PDT treatment every 6 months ...
Ten-years follow-up of photodynamic therapy for non- ...
After 2 months, PDT showed high efficacy: 94.8 % complete response in untreated nBCC, 100 % in recurrent nBCC with dermal invasion after surgery, 92.3 % in sBCC ...
Efficacy of Photodynamic Therapy vs Other Interventions in ...
Extracted Data and Outcomes of Interest. Primary outcome measures were lesion response, cosmetic results, and patient satisfaction after the ...
Umbrella review of photodynamic therapy for cancer
For patients with BCC and SCC, PDT results in higher recurrence rates than surgery, cryotherapy, and imiquimod, yet it yields superior cosmetic outcomes.
Photodynamic Therapy: Past, Current, and Future
Nearly 90% of patients in the treatment group achieved at least some improvement at week 8. All secondary efficacy endpoints were also higher in the treatment ...
Photodynamic Therapy: Occupational Hazards and ...
Direct or reflective skin and eye contact are the most important hazards posed to healthcare professionals involved with PDT treatment, whereas electrical ...
Photodynamic therapy-induced inflammation and adverse ...
PDT causes some short and long side effects including erythema, pain, swelling, redness, urticaria, Itching, dermatitis, immunosuppression, ...
Photodynamic Therapy (PDT)
... treatment. The most frequently reported adverse events (10-30%) were injection site reactions such as pain, edema, inflammation, rashes ...
Complications After Photodynamic Therapy
Photosensitivity reactions were reported in 2.2% of patients treated with PDT in the TAP and VIP trials. These were generally mild to moderate ...
Early and Late Onset Side Effects of Photodynamic Therapy
Crusting (9%), pustules (6%), erosions (1.2%) and infections (0.4%) were other reported adverse effects (Figure 3) [48]. Especially during PDT treatment of ...
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