Cancer Screening for Veterans Exposed to Burn Pits

Overseen By Salman Baig

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Inova Health Care Services

Disqualifiers: Recent malignancy, Pregnancy, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 5

What You Need to Know Before You Apply

What is the purpose of this trial?

The goal of this study is to determine the feasibility and participant satisfaction associated with a more intensive cancer screening regimen in veterans exposed to burn pits. The study results may describe the clinical and psychosocial impact such screening has on this potential population. The study hopes to share the premalignant and malignant findings identified and follow-up healthcare utilization associated with high-intensity cancer screening during the approximately 3-year study period (three annual screening assessments and an additional year of follow-up to determine participants' cancer status). The study will also explore the performance of new tools (nasal brush, multi-cancer detection blood test, and radiomic analysis) in detecting the development of cancer during the study period.

Who Is on the Research Team?

Rebecca Kaltman, MD

Principal Investigator

Inova Health Care Services

Stephanie VanBebber

Principal Investigator

Inova Health Care Services

Are You a Good Fit for This Trial?

Inclusion Criteria

* Veteran of the United States Armed Forces (retired/no longer enlisted) with a prior deployment resulting in exposure (based on self-report or official records, if available) to burn pits for \>1 week (exposure defined as on the base or close enough to the base to see the smoke from the burn pit, an area of land used for the open-air combustion of trash and other solid waste products).

I understand the study and am willing to sign the consent form.

* Ability to understand and willing to sign HIPAA Authorization

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1 day

1 visit (in-person)

Intensive Cancer Screening

Participants undergo intensive cancer screening at baseline, 12-, and 24-month visits using investigational tools like MCD blood test and nasal swabs

2 years

3 visits (in-person)

Follow-up

Participants are monitored for cancer status and healthcare utilization, with follow-up assessments at 36 months

1 year

1 visit (in-person or virtual)

Exploratory Analysis

Exploratory analysis using radiomic tools and SYBIL predictive scores to detect malignancy

2 years

What Are the Treatments Tested in This Trial?

Interventions

• Avantect Multi-Cancer Detection Test
• Nasal Swab

How Is the Trial Designed?

Group I: Veterans exposed to burn pits Experimental Treatment 2 Interventions

Veteran of the United States Armed Forces (retired/no longer enlisted) with a prior deployment resulting in exposure (based on self-report or official records, if available) to burn pits for \>1 week (exposure defined as on the base or close enough to the base to see the smoke from the burn pit, an area of land used for the open-air combustion of trash and other solid waste products).

Who Is Running the Clinical Trial?

Inova Health Care Services

Lead Sponsor

Trials

80

Recruited

22,700+