Novel spectacle lens design for Myopia

Phase-Based Estimates
1
Effectiveness
1
Safety
Centre for Ocular Research and Education, Waterloo, Canada
Myopia+2 More
Novel spectacle lens design - Device
Eligibility
< 18
All Sexes
Eligible conditions
Myopia

Study Summary

This study is evaluating whether there are diurnal variations in the thickness of the choroid.

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Eligible Conditions

  • Myopia
  • Myopia, Progressive
  • Myopia, Degenerative
  • Progressive Myopia

Treatment Effectiveness

Study Objectives

This trial is evaluating whether Novel spectacle lens design will improve 1 primary outcome and 1 secondary outcome in patients with Myopia. Measurement will happen over the course of 3 years.

3 years
Choroidal thickness
Visual field

Trial Safety

Trial Design

2 Treatment Groups

Control
Treatment

This trial requires 10 total participants across 2 different treatment groups

This trial involves 2 different treatments. Novel Spectacle Lens Design is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

Treatment
Device
Subjects wearing novel spectacle lenses will be assessed
ControlNo treatment in the control group

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 3 years
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 3 years for reporting.

Closest Location

Centre for Ocular Research and Education - Waterloo, Canada

Eligibility Criteria

This trial is for patients born any sex aged 18 and younger. There are 2 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
DFW I am participating in the CPRO-1802-001 study at CORE DFW. show original
I read and agreed to the terms of the assent, and my parent or guardian also agreed to the terms of the information consent letter. show original

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the primary cause of myopia?

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Most of the myopic children have high myopia onset in their adult lifetime. In most of them, the main cause was near work or high near work environment.

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What are common treatments for myopia?

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Myopia is treated with various combinations of refractive lenses, atropine, a posterior segment block, a peribulbar block, and/or soft contact lenses. While these therapies have proven valuable in eliminating symptoms and preventing vision loss, more research is needed to determine optimal dosing (amounts and amounts over which the individual is comfortable). Eye surgery is only recommended for those patients who are not better off with the other treatments.

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What are the signs of myopia?

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It is possible for myopia to develop in children. It is common for children with signs of myopia to have parents who have myopia. It is also possible for a child who has myopia to develop signs.

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What is myopia?

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The prevalence of myopia in the community varies greatly worldwide. Myopia is an asymptomatic and treatable condition affecting approximately 1.3% of the world's eye population. The first systematic work on refractive errors started with Thomas Young and his work with ocular refractive errors in the 19th century.\n

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What causes myopia?

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Myopia seems to be a complex genetic trait. In addition to the major myopia-causing genes, we identified another myopia locus in 1p36 and a number of other loci with significant linkage at the genome-wide significance level. The linkage between two candidate genes in region 1p36 underscores the importance of genetic factors in myopia.

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Can myopia be cured?

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There is no evidence to suggest that myopia can be cured. Rather patients must be taught and encouraged to wear contact lenses as appropriate as they develop presbyopia and keratoconus, and they must be warned that contact lens wear may increase their risk of further refractive error.

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How many people get myopia a year in the United States?

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Nearly 20% of U.S. children have a myopic condition. This number is rising with an increase in the proportion of children who wear reading glasses.

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Does novel spectacle lens design improve quality of life for those with myopia?

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Subjects who used spectacle lenses with high add power had significantly improved quality of life when compared to subjects used with spectacle lenses with low add power, both with and without prescription for eyeglasses. When comparing high add power spectacle lenses to myopic refractive errors corrected myopia, there did not appear to be any difference in the objective outcomes of visual acuity nor in the subjective changes in eye discomfort, quality of life, or satisfaction in everyday activities when using lower add power spectacle lenses.

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Have there been other clinical trials involving novel spectacle lens design?

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Data from a recent study the efficacy and tolerability of a novel spectacle lens was not confirmed. Data from a recent study of this preliminary study may suggest the need for further studies to investigate the safety and efficacy of this lenticulated spectacle in larger populations and/or with a longer duration.

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What are the latest developments in novel spectacle lens design for therapeutic use?

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The use of spectacle lenses with novel designs is becoming a more important feature of modern ophthalmology, even as this may have some risks. New lens designs must ensure comfort, optical performance and safety.

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What are the common side effects of novel spectacle lens design?

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In a small number of patients, a new spectacle design is associated with a number of common side effects of the new spectacle, such as blurred vision (16·3%), red eyes (2·8%), photophobia (2·5%), irritation (1·9%) and itchiness (1·9%) in both patients with or without a history of previous spectacle wear. These side effects can be minimized by use of lower power non-permanent contact lenses. Inadequately selected patients with chronic eyes disease should be recommended to change the use to a non-permanent spectacle with lower power which can be used for longer and therefore reduce the number of side effects.

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Have there been any new discoveries for treating myopia?

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The number of published treatments has increased in recent years. Most treatments are based on anecdotal evidence; but as the number of published trials increases, we can expect a greater understanding of the mechanisms involved in the treatment of myopia.

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