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Exercise and Bracing for Muscle Atrophy (HYPAT Trial)

N/A

Waitlist Available

Research Sponsored by McMaster University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Healthy males, between the ages of 18 and 30 y

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline, day 5, day 9 and day 14 (post)

Awards & highlights

HYPAT Trial Summary

This trial looks at the effect of immobilization and resistance exercise on muscle mass and strength.

Who is the study for?

Healthy males aged 18-30 with a BMI of 18.5 to 30 can join this study. They must be able to consent and not have muscle or bone diseases, serious illnesses, uncontrolled hypertension, diabetes, or take meds affecting protein metabolism. Non-smokers who don't drink excessively or exercise more than twice a week are eligible.Check my eligibility

What is being tested?

The trial is testing the effects of knee bracing and unilateral resistance exercise training on muscle size changes due to loading (exercise) and unloading (immobilization). It aims to understand individual molecular responses over an acute period using advanced proteomics techniques.See study design

What are the potential side effects?

Potential side effects may include discomfort from wearing the knee brace and typical exercise-related issues such as muscle soreness or strain from resistance training.

HYPAT Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I am a healthy male aged between 18 and 30.

HYPAT Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline, day 5, day 9 and day 14 (post)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline, day 5, day 9 and day 14 (post)

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, day 5, day 9 and day 14 (post) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in Dynamic Proteomics

Change in Integrated Rates of Muscle Protein Synthesis

Secondary outcome measures

Change in Lean Mass Using Dual X-Ray Absorptiometry

Change in Muscle Cross-Sectional Area using Ultrasonography

Change in Muscle Strength using an Isokinetic Dynamometer

HYPAT Trial Design

2Treatment groups

Experimental Treatment

Group I: Unilateral Resistance ExerciseExperimental Treatment1 Intervention

One leg will undergo 4 sessions of unilateral resistance exercise, over the course of 8 days. Specifically, participants will be asked to perform leg press and leg extension.

Group II: Unilateral ImmobilizationExperimental Treatment1 Intervention

One leg will undergo 14 days of single-leg immobilization, by means of a removable knee brace.

0 / 1Eligibility criteria met

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Who is running the clinical trial?

McMaster UniversityLead Sponsor

880 Previous Clinical Trials

2,597,812 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Would I be eligible for participation in this clinical trial?

"Eligible applicants for this trial must display evidence of muscle atropy and lack of physical activity, and fall between the ages 18-30. The study is actively recruiting a total of 16 participants."

Answered by AI

How many participants are the maximum capacity for this research endeavor?

"Affirmative. According to the clinicaltrials.gov portal, this study was initially posted on August 30th 2021 and has since been revised as recently as April 4th 2022. The trial is searching for 16 individuals from 1 site."

Answered by AI

Are those of mature age being considered for participation in this experiment?

"This study is open to participants aged 18 and above, but not exceeding 30 years of age."

Answered by AI

Are there still opportunities to enroll in the experiment?

"Affirmative, the information on clinicaltrials.gov implies that this trial is currently recruiting participants. Initially published on August 30th 2021, and last revised April 4th 2022, the research needs to find 16 patients from 1 specific medical centre."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Dynamic Proteomics and Integrated Rates of Muscle Protein Synthesis During an Acute Period of Loading and Unloading

Stuart Phillips 2021. "Dynamic Proteomics and Integrated Rates of Muscle Protein Synthesis During an Acute Period of Loading and Unloading". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04514744.

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