Diet Synergy for Muscle Health

(POTATO Trial)

Overseen By Nicholas A Burd (Full Professor), PhD

Age: 18 - 65

Sex: Any

Trial Phase: Academic

Sponsor: University of Illinois at Urbana-Champaign

Disqualifiers: Pregnancy, Irregular menstrual cycles, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 3

What You Need to Know Before You Apply

What is the purpose of this trial?

In the present semi-crossover randomized design, 15 recreationally active young adults (19-40 y) will receive stable isotope tracer infusions and perform a single bout of resistance exercise. Immediately after exercise, participants will ingest either 1 medium russet potato with skins and 2 ounce-equivalent lean ground beef combination (274 kcals, 19.3 g protein, 5 g fat, 37 g carbohydrates, and 4 g fiber), 2 slices of white bread and beef combination (262 kcals, 19.8 g protein, 6.8 g fat, 28 g carbohydrates, and 1.8 g fiber) or 2 ounce-equivalent beef (93% lean meat/7% fat; 110 kcals, 14.8 g protein, and 5 g fat). Repeated blood and muscle biopsies will be collected to determine whole body leucine kinetics, amino acid concentrations, anabolic signaling and myofibrillar protein synthesis rates during the trials.

Are You a Good Fit for This Trial?

This trial is for recreationally active young adults aged 19-40 who are interested in how different food combinations affect muscle protein synthesis after resistance exercise. Specific eligibility criteria details were not provided, so participants should inquire about any additional requirements.

Inclusion Criteria

Recreationally-active

Weight stable for prior 6 months

I am between 19 and 40 years old.

Exclusion Criteria

I am not between the ages of 20 and 35.

Pregnancy

Irregular menstrual cycles (i.e., around 21-day or around 35-day cycle)

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1 week

Preliminary Testing

Participants undergo preliminary testing including anthropometrics, resting metabolic rate, and 10-repetition maximum testing

1 day

1 visit (in-person)

Infusion Trials

Participants undergo stable isotope infusion trials with blood and muscle biopsies, followed by resistance exercise and meal ingestion

2 sessions, at least 7 days apart

2 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after the infusion trials

1 week

What Are the Treatments Tested in This Trial?

Interventions

• Diet Synergy

Trial Overview

The study tests the effects of consuming potato and beef, bread and beef, or just beef on muscle building after a single session of resistance exercise. Participants will undergo blood and muscle tests to see how their bodies process protein.

How Is the Trial Designed?

Group I: Potato and Beef (PB) Experimental Treatment 2 Interventions

Participants will ingest 1 medium russet potato with skins and 2 ounce-equivalent lean ground beef combination (274 kcals, 19.3 g protein, 37 g carbohydrate, 5 g fat, 4 g fiber) after resistance exercise.

Group II: Bread and Beef (BB) Experimental Treatment 2 Interventions

Participants will ingest 2 slices white bread and 2 ounce-equivalent lean ground beef combination (262 kcals, 19.8 g protein, 28 g carbohydrate, 6.8 g fat, 1.8 g fiber) after resistance exercise.

Group III: Beef (B) Experimental Treatment 2 Interventions

Participants will ingest 2 ounce-equivalent lean ground beef (110 kcals, 14.8 g protein, 5 g fat) after resistance exercise.

Who Is Running the Clinical Trial?

University of Illinois at Urbana-Champaign

Lead Sponsor

Trials

203

Recruited

40,600+