Repetitive Transcranial Magnetic Stimulation for Multiple Sclerosis
(CeV Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial examines how repetitive transcranial magnetic stimulation (rTMS) might aid individuals with multiple sclerosis (MS) in improving their walking. rTMS uses magnetic pulses to stimulate brain regions and could potentially address walking difficulties caused by MS. The trial will compare real rTMS treatment with a sham (fake) version to assess the actual changes it can produce. Individuals with MS who experience walking challenges and have not changed their MS medication in the past month might be suitable candidates for this trial. As an unphased trial, this study provides a unique opportunity to explore innovative treatment options for enhancing mobility in MS patients.
Do I need to stop taking my current medications for the trial?
The trial does not require you to stop your current medications, but you cannot start new medications for spasticity or stimulants during the study. If you are already taking fampridine, you can continue as long as you started it more than 30 days before the trial.
What prior data suggests that repetitive Transcranial Magnetic Stimulation (rTMS) is safe for people with Multiple Sclerosis?
Research has shown that repetitive transcranial magnetic stimulation (rTMS) is generally safe and well-tolerated for people with multiple sclerosis (MS). In one study, participants underwent 20 sessions of rTMS, and the results indicated that the treatment was safe and manageable. Another study found that rTMS helped reduce symptoms like muscle stiffness without causing major side effects. Overall, evidence suggests that rTMS can be a safe option for those with MS, offering potential improvements in certain symptoms without significant risks.12345
Why are researchers excited about this trial?
Repetitive Transcranial Magnetic Stimulation (rTMS) is unique because it uses magnetic pulses to stimulate specific areas of the brain, which is different from the standard treatments for multiple sclerosis (MS) that typically focus on immune system modulation or symptom management. Most MS treatments involve drugs that are administered orally or via injection to slow disease progression or manage symptoms. However, rTMS offers a non-invasive alternative that directly targets brain activity. Researchers are excited about rTMS because it could potentially improve neurological function and quality of life for MS patients without the systemic side effects associated with traditional medications.
What evidence suggests that repetitive Transcranial Magnetic Stimulation (rTMS) is effective for improving walking ability in people with Multiple Sclerosis?
Research has shown that repetitive Transcranial Magnetic Stimulation (rTMS), which participants in this trial may receive, might help people with Multiple Sclerosis (MS) walk better. Studies have found that rTMS can reduce muscle stiffness, easing movement. One study discovered that rTMS lowered the frequency and severity of muscle spasms in MS patients, with effects lasting up to a month. Additionally, rTMS has shown potential in improving other MS symptoms like depression and fatigue. These findings suggest that rTMS could be beneficial for those with MS-related walking difficulties.36789
Who Is on the Research Team?
Francois Jacques, Neurologist
Principal Investigator
Clinique Neuro-Outaouais
Are You a Good Fit for This Trial?
This trial is for adults aged 18-70 with Multiple Sclerosis (MS) who have spastic paraparesis and can walk a bit. They must be stable on their MS meds, not pregnant, and without other major health issues or neurologic disorders that could affect the study.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either active rTMS or sham rTMS for 6 weeks to study its impact on walking ability and other parameters
Follow-up
Participants are monitored for safety and effectiveness after treatment, including assessments of T25FWT and 6MWT
What Are the Treatments Tested in This Trial?
Interventions
- Repetitive Transcranial Magnetic Stimulation (rTMS)
Trial Overview
The trial tests if Repetitive Transcranial Magnetic Stimulation (rTMS), a non-invasive brain stimulation technique, improves walking in people with MS-induced leg stiffness and moderate walking disability.
How Is the Trial Designed?
2
Treatment groups
Active Control
Placebo Group
rTMS will use 100% magnetic pulses to stimulate specific areas of the brain
Sham rTMS will be conducted using the same DCC coil and MagStim machine but using only 10% of maximum machine output as stimulation intensity
Find a Clinic Near You
Who Is Running the Clinical Trial?
Clinique Neuro-Outaouais
Lead Sponsor
University of Ottawa
Collaborator
Citations
Effectiveness of Repetitive Transcranial Magnetic ...
Results from this pilot study suggested that rTMS might be routinely applied in persons with MS displaying symptoms of depression and fatigue.
Effects of repetitive transcranial magnetic stimulation in ...
Our results provide preliminary evidence for the treatment of patients with MS by rTMS, especially for improving spasticity.
Efficacy of high-frequency rTMS for cognitive impairment in ...
Our study's mean MOCA score improvement was 7.80 ± 1.37 points in RRMS and 6.13 ± 1.41 points in SPMS, so our findings exceed this estimated ...
4.
trialsjournal.biomedcentral.com
trialsjournal.biomedcentral.com/articles/10.1186/s13063-024-08425-xA phase II trial examining the safety and preliminary efficacy of ...
This study will determine if rTMS can improve functional outcomes or other MS symptoms and determine whether rTMS has the potential to promote remyelination in ...
The Effect of Repetitive Transcranial Magnetic Stimulation ...
This study found that active rTMS reduced spasticity and the spasm frequency in patients with MS. This effect was seen 1 month after the ...
A phase II trial examining the safety and preliminary ...
This study will determine if rTMS can improve functional outcomes or other MS symptoms and determine whether rTMS has the potential to promote remyelination in ...
Low-intensity repetitive transcranial magnetic stimulation is ...
Conclusion: Twenty sessions of rTMS is safe and well tolerated in a small group of people with MS. The study protocol and procedures are ...
Repetitive Transcranial Magnetic Stimulation (rTMS) in MS ...
Study Overview Study the impact of rTMS on walking ability in people with Multiple Sclerosis (MS) induced spastic paraparesis and moderate walking disability.
Low-intensity repetitive transcranial magnetic stimulation is ...
Our data indicate that 20 sessions of rTMS, delivered in an iTBS pattern over a broad cortical area, is safe, tolerable, and feasible for people ...
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