Exercise Training for Multiple Sclerosis

Overseen By Tobia Zanotto, PhD

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: University of Kansas Medical Center

Disqualifiers: Neurological conditions, Cognitive impairment, Psychiatric problems, Cardiovascular conditions, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

Duration: 6 weeks

24 Participants Needed

Trial Summary

What is the purpose of this trial?

Study Significance: This proposed investigation is designed to examine the feasibility of an exercise-based intervention to reduce frailty in people living with MS. The proposed research will be the first to establish the feasibility of targeting frailty in pwMS and will begin to examine the dynamic nature of frailty in MS. These advances will pave the way for planned prospective studies toward effective targets for diagnostics, and rehabilitation of frailty in MS.

Eligibility Criteria

This trial is for people aged 40-65 with Multiple Sclerosis (MS) who are not currently having MS relapses, can function with some disability (EDSS score ≤ 6.0), speak English, and meet at least three out of five criteria indicating frailty such as weight loss, exhaustion, weakness, slowness in walking, or low physical activity.

Inclusion Criteria

I haven't had an MS flare-up in the last month.

I can walk at least 100 meters without aid or rest.

Subjects must be fluent in spoken and written English

Exclusion Criteria

I do not have severe heart problems like dangerous irregular heartbeats or major blockages in heart arteries.

I am currently experiencing acute pain in my lower back or legs.

I have a significant neurological condition like Parkinson's or epilepsy.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants in the experimental group undergo 15 minutes of virtual reality treadmill training, 30 minutes of resistance training, and another 15 minutes of treadmill training

6 weeks

Control

Participants in the control group are placed on a waitlist for 6 weeks

6 weeks

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

Treatment Details

Interventions

• Multimodal Exercise Training

Trial Overview The study is testing whether a multimodal exercise program can reduce signs of frailty in those living with MS compared to a waitlist group. Participants will be randomly assigned to either start the exercise program immediately or placed on a waitlist as part of the control group.

Participant Groups

Group I: Multimodal Exercise Group Experimental Treatment 1 Intervention

Participants will complete 15 minutes of virtual reality treadmill training (VRTT), followed by 30 minutes of progressive evidence-based resistance training (RT), followed by other 15 minutes of VRTT.

Group II: Control Group Experimental Treatment 1 Intervention

Participants randomized to the control group will be put on a waitlist (passive control group) for 6 weeks. Upon completion of post-training assessment, participants in the control group will be able to receive the intervention, if they wish so.

Who Is Running the Clinical Trial?

University of Kansas Medical Center

Lead Sponsor

Trials

527

Recruited

181,000+