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Whole-Body MRI for Multiple Myeloma
N/A
Recruiting
Led By Ananth Madhuranthakam, PhD
Research Sponsored by University of Texas Southwestern Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Patients with pathologically confirmed myeloma
Eastern Cooperative Oncology Group (ECOG) Performance Status 0, 1, or 2
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 4 years
Awards & highlights
Study Summary
This trial will help determine if WBMRI with DETECT is more sensitive, specific, and accurate than current standard of care for detecting multiple myeloma.
Who is the study for?
This trial is for adults with confirmed multiple myeloma who can consent to the study. They must have a performance status allowing daily activity (ECOG 0-2). Women able to bear children must test negative for pregnancy. Participants should not be on other investigational treatments, pregnant, or nursing and should not have severe illnesses or conditions that MRI cannot accommodate.Check my eligibility
What is being tested?
The study tests how well whole-body MRI detects multiple myeloma compared to standard x-rays and bone marrow biopsies. It involves one-time imaging for some participants or four sessions over time—before and after bone marrow transplant or maintenance therapy—for others.See study design
What are the potential side effects?
There are generally no side effects associated with whole-body MRI itself; however, there may be discomfort from lying still during the procedure. Allergic reactions to Gadolinium-based contrast agents used in MRIs are possible but rare.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
My diagnosis is confirmed myeloma.
Select...
I can take care of myself and am up and about more than half of my waking hours.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ up to 4 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 4 years
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Assessment of therapy response
Detection of lesions
Overall Survival (OS)
+1 moreTrial Design
1Treatment groups
Experimental Treatment
Group I: Multiple Myeloma PatientsExperimental Treatment2 Interventions
Patients with pathologically confirmed myeloma for cross-sectional study (detection) or scheduled to undergo induction therapy (or have gone 1-2 cycles of induction therapy), followed by either bone marrow transplantation or consolidation therapy for longitudinal study (therapy response assessment).
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Who is running the clinical trial?
University of Texas Southwestern Medical CenterLead Sponsor
1,047 Previous Clinical Trials
1,053,759 Total Patients Enrolled
2 Trials studying Multiple Myeloma
729 Patients Enrolled for Multiple Myeloma
Ananth Madhuranthakam, PhDPrincipal Investigator - UT Southwestern Medical Center
University of Texas Southwestern Medical Center
1 Previous Clinical Trials
40 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I do not have any severe illnesses or social situations that would stop me from following the study's requirements.You have a condition that makes it unsafe for you to have an MRI scan according to the hospital's rules.You have had a serious allergic reaction to Gadolinium-based contrast agents.I am scheduled for or have started induction therapy and will have a bone marrow biopsy, followed by transplantation or consolidation therapy.I am a woman who can become pregnant and agree to a pregnancy test before imaging.My diagnosis is confirmed myeloma.I can undergo an MRI despite my claustrophobia, back pain, or tremors.I can take care of myself and am up and about more than half of my waking hours.
Research Study Groups:
This trial has the following groups:- Group 1: Multiple Myeloma Patients
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are additional participants being sought for this research endeavor?
"Clinicaltrials.gov states that this medical trial is now open for recruitment, having first been posted on November 30th 2020 and most recently revised on August 29th 2022."
Answered by AI
How many participants are being enrolled for this research project?
"Indeed, the information on clinicaltrials.gov attests to this trial's ongoing recruitment of patients. Initially posted in November 2020 and recently modified in August 2022, it is looking for 40 volunteers at a single site."
Answered by AI
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