Treatment for Cancer Pain

Phase-Based Progress Estimates
1
Effectiveness
1
Safety
New York University College of Dentistry, New York, NY
Cancer Pain+3 More
Eligibility
18+
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether a chemical sensitivity test can help identify the pain phenotype in oral cancer patients.

See full description

Eligible Conditions

  • Cancer Pain
  • Oral Squamous Cell Carcinoma (OSCC)

Treatment Effectiveness

Effectiveness Progress

1 of 3

Study Objectives

This trial is evaluating whether Treatment will improve 2 primary outcomes in patients with Cancer Pain. Measurement will happen over the course of Baseline visit.

Baseline visit
Chemical Sensitivity
Mechanical Sensitivity

Trial Safety

Safety Progress

1 of 3

Trial Design

0 Treatment Group

This trial requires 80 total participants across 0 different treatment group

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline visit
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly baseline visit for reporting.

Who is running the study

Principal Investigator
B. L. S.
Brian L. Schmidt, Director of Bluestone Center for Clinical Research
NYU College of Dentistry

Closest Location

New York University College of Dentistry - New York, NY

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 2 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
is associated with significantly higher risks of locoregional recurrence (LRR) and overall mortality (OM) than SCC that does not require surgical resection show original
The lesion is at least 1 cm wide. show original

Patient Q&A Section

What are the chances of developing cancer pain?

"About 20% to 26% of patients with unresectable non-small-cell [lung cancer](https://www.withpower.com/clinical-trials/lung-cancer) will develop cancer pain during the course of their illness, and this proportion rises to 43% to 48% in NSCLC patients who receive chemotherapy. In addition to being a symptom of cancer, cancer pain can be painful enough to interfere with patients' daily activities. Despite its prevalence, Cancer Pain hasn't been regarded as an independent dimension of distress in the draft version of the McGill Pain Questionnaire. It's worth noting that only 12% of patients reported trouble paying attention due to their pain." - Anonymous Online Contributor

Unverified Answer

Have there been other clinical trials involving treatment?

"There were no clinical trials registered in Desitin at the time of writing this question. power has not yet conducted any clinical trials specifically related to Desitin. However, due to their wide spectrum of clinical applications, they may have previously conducted clinical trials on the related therapies.\n" - Anonymous Online Contributor

Unverified Answer

What does treatment usually treat?

"When patients with advanced cancer start to experience many painful symptoms from their cancer, they often try to relieve them with medication. However, there is little evidence that any particular treatment is consistently better than another when treating the same symptoms." - Anonymous Online Contributor

Unverified Answer

What is cancer pain?

"Cancer pain is an issue that deserves attention. What is more important than knowing the steps needed to treat cancer pain is knowing what cancer pain looks like." - Anonymous Online Contributor

Unverified Answer

What are the latest developments in treatment for therapeutic use?

"Presenting new therapy concepts requires careful validation of their safety and efficacy before they are deployed in practice. The current emphasis on the development and deployment of novel biologic agents has led to significant advances in the management of cancer pain. New pharmacotherapies appear to be safe and effective alternatives to opioids in the treatment of moderate to severe cancer pain." - Anonymous Online Contributor

Unverified Answer

What causes cancer pain?

"Cancer pain can be caused by the tumour itself, metastasis, inflammation at the site of the tumour, nerve damage, or other causes. Rarely, cancer pain has psychiatric origins. The diagnosis of cancer pain requires determination of the type of cancer, its stage, the presence or absence of metastatic disease, and the probable locus of pain. Cancer pain management involves assessing the possibilities of alleviating cancer pain and preventing enduring pain after treatment. Pain management encompasses all aspects of the cancer patient's care including primary and secondary prevention, palliative care, and managing acute cancer pain." - Anonymous Online Contributor

Unverified Answer

What is treatment?

"Patients with advanced cancers experience significant pain (both psychological and physical), particularly from palliative care. There is a gap between what patients want and what their healthcare providers recommend, especially for psychological issues like depression and anxiety. A multidisciplinary approach is necessary to address patient preferences and clinician recommendations." - Anonymous Online Contributor

Unverified Answer

Is treatment typically used in combination with any other treatments?

"The authors found that over two-third of the respondents reported being given at least one other treatment prior to starting their current therapy. The authors therefore recommend that clinicians consider the patient's history when prescribing the optimal regimen for treatment of cancer pain." - Anonymous Online Contributor

Unverified Answer

Can cancer pain be cured?

"Despite ongoing efforts to develop effective treatments for cancer pain, there remain no validated standard therapies. The question remains whether these compounds that are known to control other chronic diseases have potential for treating cancer pain as well. We provide preliminary evidence suggesting that nociception-related compounds may induce analgesia and alleviate pain in cancer patients. Results from a recent paper warrant further investigation of anticancer nociceptive drugs as potential novel strategies for managing cancer pain." - Anonymous Online Contributor

Unverified Answer

Have there been any new discoveries for treating cancer pain?

"There has been little progress made in cancer [pain management](https://www.withpower.com/clinical-trials/pain-management) since the 1990s. However, recent advances have led to more effective treatment options. ITP is now used in combination with opiate analgesia in patients with moderate-severe cancer pain. New drugs, such as [ketorolac] (Zaditor) are being developed to treat cancer pain. [Ketorolac] is available in the US under prescription only, but should not be given to people without a prescription because it increases the risk of heart attack, stroke, and death. Other medications that are being considered for use as adjuvants in some cancers include almotriptan, tramadol, and other opioids such as oxycodone." - Anonymous Online Contributor

Unverified Answer

Has treatment proven to be more effective than a placebo?

"A survey of cancer patients attending a palliative care service found only modest evidence that opioid medications may not result in improved pain relief when compared with a placebo. Previous studies tend to overestimate the effectiveness of opioids; this suggests a need for further research into this area." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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